iPTMnet Report for Q8N726 (CDKN2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N726 / ARF_HUMAN
Protein Name Tumor suppressor ARF
Gene Name Name: CDKN2A
Synonyms:CDKN2;
Organism Homo sapiens (Human)

PRO ID PR:Q8N726
DAG View
PRO Name tumor suppressor ARF/smARF (human)
Definition A CDKN2A gene translation product (human), isoforms ARF and smARF.
Short Label hCDKN2A/iso:[ARF/smARF]
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species


Q8N726 (CDKN2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus 23308265
T8 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 23308265
T31 Phosphorylation PhosphoSitePlus
R115 Methylation PhosphoSitePlus
R120 Methylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
R129 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R68 Methylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
R75 Methylation PhosphoSitePlus
R82 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T8 A8 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R115 W115 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R115 L115 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R120 S120 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R120 H120 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R120 C120 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R122 Q122 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R122 P122 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1245 / vulva cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R122 L122 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R122 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R129 L129 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R129 C129 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R129 G129 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]