iPTMnet Report Q8N726 CDKN2A

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q8N726 / ARF_HUMAN
Protein Name	Tumor suppressor ARF
Gene Name	Name: CDKN2A Synonyms:CDKN2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q8N726 DAG View
PRO Name	tumor suppressor ARF/smARF (human)
Definition	A CDKN2A gene translation product (human), isoforms ARF and smARF.
Short Label	hCDKN2A/iso:[ARF/smARF]
Category	organism-seqgroup

Interactive Sequence View

	Select/align proteoforms across species

Q8N726 (CDKN2A) as Substrate

Condensed View

Search:

	Site Select all By amino acid All Threonine By position T8 T31 R115 R120 R122 R129	PTM Type Select all Methylation Phosphorylation	PTM Enzyme Select all P17252 (PRKCA)	Score Select all 1 2	Source Select all PhosphoSitePlus	PMID
	T8	Phosphorylation		score2	PhosphoSitePlus	23308265
	T8	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	23308265
	T31	Phosphorylation		score1	PhosphoSitePlus
	R115	Methylation		score1	PhosphoSitePlus
	R120	Methylation		score1	PhosphoSitePlus
	R122	Methylation		score1	PhosphoSitePlus
	R129	Methylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid By position R68 R73 R75 R82	PTM Type Select all Methylation	PTM Enzyme Select all	Score Select all 1	Source Select all PhosphoSitePlus	PMID
	R68	Methylation		score1	PhosphoSitePlus
	R73	Methylation		score1	PhosphoSitePlus
	R75	Methylation		score1	PhosphoSitePlus
	R82	Methylation		score1	PhosphoSitePlus

PTM sites affected in variants

Search:

Site Select all By amino acid All Threonine By position T8 R115 R120 R122 R129	Variant Select all * A8 C120 C129 G129 H120 L115 L122 L129 P122 Q122 S120 W115	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1245 / vulva cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T8	A8	Biomuta		DOID:5041 / esophageal cancer [ cosmic ]
R115	W115	Biomuta		DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R115	L115	Biomuta		DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R120	S120	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
R120	H120	Biomuta		DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R120	C120	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
R122	Q122	Biomuta		DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R122	P122	Biomuta		DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1245 / vulva cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R122	L122	Biomuta		DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R122	*	Biomuta		DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R129	L129	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R129	C129	Biomuta		[ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R129	G129	Biomuta		DOID:1793 / pancreatic cancer [ cosmic ]