iPTMnet Report for Q8N6T7 (SIRT6)
Protein Information
UniProt AC / UniProt ID | Q8N6T7 / SIR6_HUMAN |
Protein Name | NAD-dependent protein deacetylase sirtuin-6 |
Gene Name | Name: SIRT6 Synonyms:SIR2L6; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q8N6T7 |
PRO Name | NAD-dependent protein deacetylase sirtuin-6 (human) |
Definition | An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of human. |
Short Label | hSIRT6 |
Category | organism-gene |
Q8N6T7 (SIRT6) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Acetylation | score1 | UniProt | 19413330 | ||
S10 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K17 | Ubiquitination | score1 | PhosphoSitePlus | |||
K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
K128 | Ubiquitination | score1 | PhosphoSitePlus | |||
T146 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y148 | Phosphorylation | score1 | PhosphoSitePlus | |||
K160 | Ubiquitination | score1 | PhosphoSitePlus | |||
T162 | Phosphorylation | score1 | PhosphoSitePlus | |||
K170 | Ubiquitination | score1 | PhosphoSitePlus | |||
K245 | Ubiquitination | score1 | PhosphoSitePlus | |||
K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
T294 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 30504065, 18669648, 24275569 | ||
S303 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
T305 | Phosphorylation | score1 | PhosphoSitePlus | |||
S310 | Phosphorylation | score1 | PhosphoSitePlus | |||
S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
S330 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T337 | Phosphorylation | score1 | PhosphoSitePlus | |||
S338 | Phosphorylation | P31749 (AKT1) | score4 | PhosphoSitePlus RLIMS-P | 24163442, 25074979 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S2 | P2 | Biomuta | DOID:3571 / liver cancer [ tcga ] | |
K81 | N81 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K81 | R81 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
T146 | M146 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
K245 | * | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] | |
T294 | P294 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] | |
S303 | Y303 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S330 | R330 | Biomuta | DOID:1115 / sarcoma [ tcga ] | |
S338 | R338 | Biomuta | DOID:3571 / liver cancer [ icgc ] |