iPTMnet Report for Q8N6T7 (SIRT6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N6T7 / SIR6_HUMAN
Protein Name NAD-dependent protein deacetylase sirtuin-6
Gene Name Name: SIRT6
Synonyms:SIR2L6;
Organism Homo sapiens (Human)

PRO ID PR:Q8N6T7
DAG View
PRO Name NAD-dependent protein deacetylase sirtuin-6 (human)
Definition An NAD-dependent protein deacetylase sirtuin-6 that is encoded in the genome of human.
Short Label hSIRT6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N6T7 (SIRT6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S10 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 27568560
K17 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
T294 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 30504065, 18669648, 24275569, ...27568560
S303 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 27568560
T305 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 27568560
T337 Phosphorylation PhosphoSitePlus
S338 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 24163442, 25074979, 27746184, ...30518851, 27568560


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8N6T7 (SIRT6) S338 O60885 (BRD4) inhibited_association eFIP 30518851


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 P2 Biomuta DOID:3571 / liver cancer [ tcga ]
K81 N81 Biomuta DOID:1324 / lung cancer [ cosmic ]
K81 R81 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T146 M146 Biomuta DOID:363 / uterine cancer [ tcga ]
K245 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T294 P294 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S303 Y303 Biomuta DOID:363 / uterine cancer [ tcga ]
S330 R330 Biomuta DOID:1115 / sarcoma [ tcga ]
S338 R338 Biomuta DOID:3571 / liver cancer [ icgc ]