iPTMnet Report for Q8N6R0 (METTL13)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N6R0 / EFNMT_HUMAN
Protein Name eEF1A lysine and N-terminal methyltransferase
Gene Name Name: METTL13
Synonyms:EEF1AKNMT;ORFNames:CGI-01;
Organism Homo sapiens (Human)

PRO ID PR:Q8N6R0
DAG View
PRO Name eEF1A lysine and N-terminal methyltransferase (human)
Definition An eEF1A lysine and N-terminal methyltransferase that is encoded in the genome of human.
Short Label hMETTL13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N6R0 (METTL13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K6 Ubiquitination PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
K19 Sumoylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
Y35 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S267 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y282 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S463 O-Glycosylation GlyGen 23301498, 28411811, 29351928
K466 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
T662 Phosphorylation PhosphoSitePlus
T668 Phosphorylation PhosphoSitePlus
Y687 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S181 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S267 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 T6 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y16 C16 Biomuta DOID:263 / kidney cancer [ cosmic ]
K19 T19 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S181 G181 Biomuta [ cosmic ]
S267 G267 Biomuta [ cosmic ]
Y282 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S289 I289 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K322 E322 Biomuta [ cosmic ]
Y398 F398 Biomuta DOID:3571 / liver cancer [ cosmic ]
K408 R408 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K447 N447 Biomuta DOID:5158 / pleural cancer [ cosmic ]
K447 R447 Biomuta DOID:3571 / liver cancer [ cosmic ]
K600 N600 Biomuta DOID:363 / uterine cancer [ icgc ]
S603 N603 Biomuta DOID:1324 / lung cancer [ cosmic ]