Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N684 / CPSF7_HUMAN
Protein Name Cleavage and polyadenylation specificity factor subunit 7
Gene Name Name: CPSF7
Organism Homo sapiens (Human)

PRO ID PR:Q8N684
DAG View
PRO Name cleavage and polyadenylation specificity factor subunit 7 (human)
Definition A cleavage and polyadenylation specificity factor subunit 7 that is encoded in the genome of human.
Short Label hCPSF7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N684 (CPSF7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y31 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S48 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y72 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
T73 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
Y74 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K148 Sumoylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
T203 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
S205 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S212 Phosphorylation PhosphoSitePlus
R227 Methylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
S348 O-Glycosylation GlyGen 32119511, 28411811, 28510447, ...29351928
S348 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S413 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S415 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S423 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S427 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S429 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S431 Phosphorylation PhosphoSitePlus
R447 Methylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S89 Phosphorylation HPRD 19664995
S90 Phosphorylation HPRD 19664995
S91 Phosphorylation HPRD 19664995
S103 Phosphorylation HPRD 19651622, 20068231
Y115 Phosphorylation HPRD 15144186
S237 Phosphorylation HPRD 19664994, 20068231
S238 Phosphorylation HPRD 19664994
S240 Phosphorylation HPRD 18669648, 17287340
T246 Phosphorylation HPRD 18669648
S248 Phosphorylation HPRD 18669648
S365 Phosphorylation HPRD 20068231
S452 Phosphorylation HPRD 16964243, 20068231
S456 Phosphorylation HPRD 18669648, 20068231, 17924679
S459 Phosphorylation HPRD 16964243, 20068231
S460 Phosphorylation HPRD 20068231
S466 Phosphorylation HPRD 17081983, 20068231
S470 Phosphorylation HPRD 20068231
S472 Phosphorylation HPRD 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S46 R46 Biomuta DOID:363 / uterine cancer [ tcga ]
Y72 H72 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y74 H74 Biomuta DOID:1324 / lung cancer [ cosmic ]
K148 T148 Biomuta DOID:3070 / malignant glioma [ tcga ]
S325 L325 Biomuta DOID:363 / uterine cancer [ tcga ]
S394 Y394 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S429 R429 Biomuta DOID:3571 / liver cancer [ icgc ]
R447 W447 Biomuta DOID:1793 / pancreatic cancer [ tcga ]