iPTMnet Report for Q8N5V2 (NGEF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N5V2 / NGEF_HUMAN
Protein Name Ephexin-1
Gene Name Name: NGEF
Organism Homo sapiens (Human)

PRO ID PR:Q8N5V2
DAG View
PRO Name ephexin-1 (human)
Definition An ephexin-1 that is encoded in the genome of human.
Short Label hNGEF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N5V2 (NGEF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
Y179 Phosphorylation PRO
K185 Ubiquitination PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
Y289 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
Y537 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048600 (hNGEF/Phos:1) pY179 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 I57 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S63 F63 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K185 I185 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K234 N234 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K492 N492 Biomuta DOID:363 / uterine cancer [ icgc ]
S606 L606 Biomuta DOID:4159 / skin cancer [ cosmic ]