Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N5S9 / KKCC1_HUMAN
Protein Name Calcium/calmodulin-dependent protein kinase kinase 1
Gene Name Name: CAMKK1
Synonyms:CAMKKA;
Organism Homo sapiens (Human)

PRO ID PR:Q8N5S9
DAG View
PRO Name calcium/calmodulin-dependent protein kinase kinase 1 (human)
Definition A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human.
Short Label hCAMKK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N5S9 (CAMKK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S52 Phosphorylation neXtProt   PhosphoSitePlus 11574070, 10187789, 18242179
S67 Phosphorylation PhosphoSitePlus   UniProt 23186163
S69 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S74 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P 11574070, 10187789, 18242179
S82 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
R102 Methylation PhosphoSitePlus
T108 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 11574070, 10187789, 18242179
K277 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S458 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 11574070, 23186163, ...18242179, 10187789, 24275569
R469 Methylation PhosphoSitePlus
R472 Methylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S475 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P 11574070, 10187789, 18242179
S492 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
S74 Phosphorylation HPRD 18691976, 11574070, 10187789
S97 Phosphorylation HPRD 18691976, 20068231
S100 Phosphorylation HPRD 18691976
T108 Phosphorylation HPRD 11574070, 10187789
S458 Phosphorylation HPRD 18691976, 11574070, 18212344, ...20068231
S475 Phosphorylation HPRD 11574070
S492 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S74 Phosphorylation HPRD 18691976, 11574070, 10187789
S97 Phosphorylation HPRD 18691976, 20068231
S100 Phosphorylation HPRD 18691976
T108 Phosphorylation HPRD 11574070, 10187789
S496 Phosphorylation HPRD 18691976, 11574070, 18212344, ...20068231
S513 Phosphorylation HPRD 11574070


Q8N5S9 (CAMKK1) as PTM Enzyme



Substrate Site Score Source PMID
P31749-1 (AKT1) T308 HPRD   neXtProt 9859994, 10833263
Q13131 (PRKAA1) T183 neXtProt   PhosphoSitePlus   Signor 23583109, 15980064, 21918180
Q14012 (CAMK1) T177 neXtProt   PhosphoSitePlus 15173201, 17287469, 7641687
Q16566 (CAMK4) S12 PhosphoSitePlus 8702940
Q16566 (CAMK4) S13 PhosphoSitePlus 8702940
Q16566 (CAMK4) T200 HPRD   neXtProt   PhosphoSitePlus   Signor 8702940, 8621423, 9163534, ...15769749, 7615569, 15143065, 10833263
Q8IU85-1 (CAMK1D) T180 HPRD   neXtProt   PhosphoSitePlus 12935886, 18669648
Q8TDC3 (BRSK1) T189 neXtProt 19958286, 18324781
Q8TDC3-2 (BRSK1) T205 PhosphoSitePlus 19958286


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046560 (hCAMKK1/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T93 M93 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
T93 R93 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S97 R97 Biomuta DOID:1115 / sarcoma [ tcga ]
S100 F100 Biomuta DOID:1324 / lung cancer [ cosmic ]
S100 P100 Biomuta DOID:363 / uterine cancer [ tcga ]
T108 N108 Biomuta DOID:3571 / liver cancer [ icgc ]
T446 M446 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S458 F458 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S475 F475 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]