iPTMnet Report for Q8N5S9 (CAMKK1)
Protein Information
| UniProt AC / UniProt ID | Q8N5S9 / KKCC1_HUMAN |
| Protein Name | Calcium/calmodulin-dependent protein kinase kinase 1 |
| Gene Name | Name: CAMKK1 Synonyms:CAMKKA; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8N5S9 |
| PRO Name | calcium/calmodulin-dependent protein kinase kinase 1 (human) |
| Definition | A calcium/calmodulin-dependent protein kinase kinase 1 that is encoded in the genome of human. |
| Short Label | hCAMKK1 |
| Category | organism-gene |
DAG ViewQ8N5S9 (CAMKK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Phosphorylation | score1 | PRO | ||||
| S52 | Phosphorylation | score4 | neXtProt PhosphoSitePlus | 11574070, 10187789, 18242179 | ||
| S67 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S74 | Phosphorylation | P17612 (PRKACA) | score4 | neXtProt PhosphoSitePlus RLIMS-P | 11574070, 10187789, 18242179 | |
| S82 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y83 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T93 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S100 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R102 | Methylation | score1 | PhosphoSitePlus | |||
| T108 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P | 11574070, 10187789, 18242179 | ||
| K277 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S443 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T446 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S452 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S458 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 18691976, 11574070, 23186163, ... | ||
| R469 | Methylation | score1 | PhosphoSitePlus | |||
| R472 | Methylation | score1 | PhosphoSitePlus | |||
| S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S475 | Phosphorylation | P17612 (PRKACA) | score4 | neXtProt PhosphoSitePlus RLIMS-P | 11574070, 10187789, 18242179 | |
| S492 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S74 | Phosphorylation | score2 | HPRD | 18691976, 11574070, 10187789 | ||
| S97 | Phosphorylation | score0 | HPRD | 18691976, 20068231 | ||
| S100 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T108 | Phosphorylation | score2 | HPRD | 11574070, 10187789 | ||
| S458 | Phosphorylation | score2 | HPRD | 18691976, 11574070, 18212344, ... | ||
| S475 | Phosphorylation | score1 | HPRD | 11574070 | ||
| S492 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S74 | Phosphorylation | score2 | HPRD | 18691976, 11574070, 10187789 | ||
| S97 | Phosphorylation | score0 | HPRD | 18691976, 20068231 | ||
| S100 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T108 | Phosphorylation | score2 | HPRD | 11574070, 10187789 | ||
| S496 | Phosphorylation | score2 | HPRD | 18691976, 11574070, 18212344, ... | ||
| S513 | Phosphorylation | score1 | HPRD | 11574070 |
Q8N5S9 (CAMKK1) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P31749-1 (AKT1) | T308 | score4 | HPRD neXtProt | 9859994, 10833263 | |
| Q13131 (PRKAA1) | T183 | score4 | neXtProt PhosphoSitePlus Signor | 23583109, 15980064, 21918180 | |
| Q14012 (CAMK1) | T177 | score4 | neXtProt PhosphoSitePlus | 15173201, 17287469, 7641687 | |
| Q16566 (CAMK4) | S12 | score2 | PhosphoSitePlus | 8702940 | |
| Q16566 (CAMK4) | S13 | score2 | PhosphoSitePlus | 8702940 | |
| Q16566 (CAMK4) | T200 | score4 | HPRD neXtProt PhosphoSitePlus Signor | 8702940, 8621423, 9163534, ... | |
| Q8IU85-2 (CAMK1D) | T180 | score4 | HPRD neXtProt PhosphoSitePlus | 12935886, 18669648 | |
| Q8TDC3 (BRSK1) | T189 | score3 | neXtProt | 19958286, 18324781 | |
| Q8TDC3-2 (BRSK1) | T205 | score2 | PhosphoSitePlus | 19958286 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S69 | L69 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| T93 | M93 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
| T93 | R93 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| S97 | R97 | Biomuta | [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc, tcga ] | |
| S100 | F100 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S100 | P100 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T446 | M446 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S458 | F458 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S473 | F473 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S475 | F475 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S496 | F496 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S513 | F513 | Biomuta | DOID:4159 / skin cancer [ cosmic ] [ cosmic ] DOID:1115 / sarcoma [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |
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