iPTMnet Report for Q8N5G2 (MACO1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N5G2 / MACOI_HUMAN
Protein Name Macoilin
Gene Name Name: MACO1
Synonyms:TMEM57;
Organism Homo sapiens (Human)

PRO ID PR:Q8N5G2
DAG View
PRO Name macoilin (human)
Definition A macoilin that is encoded in the genome of human.
Short Label hMACO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N5G2 (MACO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K177 Ubiquitination PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus   UniProt 23186163
T306 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S337 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
T357 O-Glycosylation GlyGen 30379171
T357 Phosphorylation PhosphoSitePlus
S358 O-Glycosylation GlyGen 30379171
K365 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K472 Acetylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
T551 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
S631 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S634 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S637 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T647 Phosphorylation PhosphoSitePlus
S648 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S650 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
Y659 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T306 Phosphorylation HPRD 19664994
S326 Phosphorylation HPRD 20068231
S331 Phosphorylation HPRD 20068231
S332 Phosphorylation HPRD 19651622, 18669648, 19007248, ...20068231
S631 Phosphorylation HPRD 18669648
S634 Phosphorylation HPRD 18669648
S637 Phosphorylation HPRD 18669648
S648 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K177 N177 Biomuta DOID:1319 / brain cancer [ icgc ]
K323 R323 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S331 C331 Biomuta DOID:1324 / lung cancer [ cosmic ]
K537 T537 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S584 F584 Biomuta DOID:4159 / skin cancer [ cosmic ]
S631 I631 Biomuta DOID:3571 / liver cancer [ cosmic ]
S637 F637 Biomuta DOID:4159 / skin cancer [ cosmic ]
T647 P647 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S648 G648 Biomuta DOID:1324 / lung cancer [ cosmic ]
S648 I648 Biomuta DOID:1324 / lung cancer [ cosmic ]