Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N5F7 / NKAP_HUMAN
Protein Name NF-kappa-B-activating protein
Gene Name Name: NKAP
Organism Homo sapiens (Human)

PRO ID PR:Q8N5F7
DAG View
PRO Name NF-kappa-B-activating protein (human)
Definition An NF-kappa-B-activating protein that is encoded in the genome of human.
Short Label hNKAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N5F7 (NKAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 17081983
S7 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983
S9 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983
S15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus   UniProt 23186163
S64 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18077418
S67 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K112 Acetylation PhosphoSitePlus   UniProt 19608861
S149 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15302935, 16097034, 18707149, ...18691976, 21406692, 23186163, 20230923, 18452278, 19690332, 19413330, 18767875, 20058876, 19651622, 15345747, 18491316, 17081983, 19664994, 19664995, 18669648, 19415658, 20068231
K151 Ubiquitination PhosphoSitePlus
S157 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 19651622, 23186163
T161 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 19651622, 23186163
S171 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S262 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S264 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S265 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S266 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S269 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
K283 Sumoylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
R334 Methylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S64 C64 Biomuta DOID:263 / kidney cancer [ cosmic ]
S149 P149 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
K151 N151 Biomuta DOID:363 / uterine cancer [ tcga ]
S157 F157 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S171 I171 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
T172 N172 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S224 N224 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S262 R262 Biomuta DOID:1324 / lung cancer [ cosmic ]
S262 G262 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S357 R357 Biomuta DOID:3571 / liver cancer [ icgc ]