iPTMnet Report Q8N5C8 TAB3

Protein Information

UniProt AC / UniProt ID	Q8N5C8 / TAB3_HUMAN
Protein Name	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Gene Name	Name: TAB3 Synonyms:MAP3K7IP3;
Organism	Homo sapiens (Human)

PRO ID	PR:Q8N5C8 DAG View
PRO Name	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (human)
Definition	A TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 that is a translation product of the TAB3 that is encoded in the genome of human.
Short Label	hTAB3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q8N5C8 (TAB3) as Substrate

Q8N5C8

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position A2 S5 Y53 Y55 Y58 S60 S80 S82 S83 Y84 T97 S101 S102 S103 S126 T134 Y224 T235 S238 R264 K283 T354 S385 T404 S407 S408 S409 S411 Y428 T440 S442 S444 S492 S504 S506 Y512 S563 Y613 S627 S645 K649 T657 T667 S672	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Ubiquitination	Score Select all 1 2 3 4	Source Select all GlyGen PhosphoSitePlus RLIMS-P UniProt phospho.ELM	PMID
A2	Acetylation	score1	UniProt	20068231
S5	Phosphorylation	score1	PhosphoSitePlus
Y53	Phosphorylation	score1	PhosphoSitePlus
Y55	Phosphorylation	score1	PhosphoSitePlus
Y58	Phosphorylation	score1	PhosphoSitePlus
S60	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 20068231
S80	Phosphorylation	score1	PhosphoSitePlus
S82	Phosphorylation	score1	PhosphoSitePlus
S83	Phosphorylation	score1	PhosphoSitePlus
Y84	Phosphorylation	score1	PhosphoSitePlus
T97	Phosphorylation	score1	PhosphoSitePlus
S101	Phosphorylation	score2	PhosphoSitePlus UniProt	24275569
S102	Phosphorylation	score1	PhosphoSitePlus
S103	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S126	Phosphorylation	score1	PhosphoSitePlus
T134	Phosphorylation	score1	PhosphoSitePlus
Y224	Phosphorylation	score1	PhosphoSitePlus
T235	O-Glycosylation	score3	GlyGen	23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
S238	O-Glycosylation	score3	GlyGen	23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
R264	Methylation	score1	PhosphoSitePlus
K283	Methylation	score1	PhosphoSitePlus
T354	Phosphorylation	score1	PhosphoSitePlus
S385	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
T404	Phosphorylation	score4	PhosphoSitePlus RLIMS-P UniProt	27009840, 23186163, 18669648
S407	Phosphorylation	score1	phospho.ELM	18669648
S408	O-Glycosylation	score4	GlyGen PhosphoSitePlus	23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
S408	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
S409	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S411	O-Glycosylation	score3	GlyGen	23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
Y428	Phosphorylation	score1	PhosphoSitePlus
T440	Phosphorylation	score1	PhosphoSitePlus
S442	Phosphorylation	score1	PhosphoSitePlus
S444	Phosphorylation	score1	PhosphoSitePlus
S492	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	18669648
S504	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18669648
S506	Phosphorylation	score4	phospho.ELM PhosphoSitePlus UniProt	18669648, 18021073
Y512	Phosphorylation	score1	PhosphoSitePlus
S563	Phosphorylation	score1	PhosphoSitePlus
Y613	Phosphorylation	score1	PhosphoSitePlus
S627	Phosphorylation	score1	PhosphoSitePlus
S645	Phosphorylation	score1	PhosphoSitePlus
K649	Ubiquitination	score2	UniProt	36593296
T657	Phosphorylation	score1	PhosphoSitePlus
T667	O-Glycosylation	score3	GlyGen	23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
S672	O-Glycosylation	score3	GlyGen	23301498, 30379171, 27009840, ...29351928, 34019948, 31492838

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y53 S82 S83 S101 S126 T235 R264 T354 T404 S409 S411 T440 S442 S563 Y613 K649	Variant Select all * A409 C563 E649 F409 F613 H264 H53 I101 I440 K235 L411 L442 M404 S354 T82 T83	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] [ cosmic ]
Y53	H53	Biomuta	DOID:363 / uterine cancer [ icgc ]
S82	T82	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S83	T83	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S101	I101	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S126	*	Biomuta	DOID:1612 / breast cancer [ cosmic ]
T235	K235	Biomuta	DOID:3571 / liver cancer [ cosmic ]
R264	H264	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
T354	S354	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T404	M404	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S409	A409	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S409	F409	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S411	L411	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
T440	I440	Biomuta	[ cosmic ]
S442	L442	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S563	C563	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y613	F613	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K649	E649	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q8N5C8 (TAB3)

Protein Information

Interactive Sequence View

Q8N5C8 (TAB3) as Substrate

PTM sites affected in variants