iPTMnet Report for Q8N5C8 (TAB3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N5C8 / TAB3_HUMAN
Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Gene Name Name: TAB3
Synonyms:MAP3K7IP3;
Organism Homo sapiens (Human)

PRO ID PR:Q8N5C8
DAG View
PRO Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (human)
Definition A TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 that is a translation product of the TAB3 that is encoded in the genome of human.
Short Label hTAB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N5C8 (TAB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 20068231
S5 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
S60 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S80 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   UniProt 24275569
S102 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus   UniProt 23186163
S126 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
T235 O-Glycosylation GlyGen 23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
S238 O-Glycosylation GlyGen 23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
R264 Methylation PhosphoSitePlus
K283 Methylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus   UniProt 23186163
T404 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27009840, 23186163, 18669648
S407 Phosphorylation phospho.ELM 18669648
S408 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
S408 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S409 Phosphorylation PhosphoSitePlus   UniProt 23186163
S411 O-Glycosylation GlyGen 23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
Y428 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S492 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S504 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S506 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18021073
Y512 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
Y613 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
K649 Ubiquitination UniProt 36593296
T657 Phosphorylation PhosphoSitePlus
T667 O-Glycosylation GlyGen 23301498, 30379171, 27009840, ...29351928, 34019948, 31492838
S672 O-Glycosylation GlyGen 23301498, 30379171, 27009840, ...29351928, 34019948, 31492838


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y53 H53 Biomuta DOID:363 / uterine cancer [ icgc ]
S82 T82 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S83 T83 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S101 I101 Biomuta DOID:1324 / lung cancer [ cosmic ]
S126 * Biomuta DOID:1612 / breast cancer [ cosmic ]
T235 K235 Biomuta DOID:3571 / liver cancer [ cosmic ]
R264 H264 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T354 S354 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T404 M404 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S409 A409 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S409 F409 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S411 L411 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T440 I440 Biomuta [ cosmic ]
S442 L442 Biomuta DOID:1324 / lung cancer [ cosmic ]
S563 C563 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y613 F613 Biomuta DOID:4159 / skin cancer [ cosmic ]
K649 E649 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]