iPTMnet Report for Q8N556 (AFAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N556 / AFAP1_HUMAN
Protein Name Actin filament-associated protein 1
Gene Name Name: AFAP1
Synonyms:AFAP;
Organism Homo sapiens (Human)

PRO ID PR:Q8N556
DAG View
PRO Name actin filament-associated protein 1 (human)
Definition An actin filament-associated protein 1 that is encoded in the genome of human.
Short Label hAFAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N556 (AFAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
Y19 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus 9655255
Y93 Phosphorylation P12931 (SRC) PhosphoSitePlus 9655255
Y94 Phosphorylation PhosphoSitePlus 9655255
Y94 Phosphorylation P12931 (SRC) PhosphoSitePlus 9655255
S101 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus 9655255
Y125 Phosphorylation P12931 (SRC) PhosphoSitePlus 9655255
K208 Acetylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus 18577577
S277 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 18577577
S278 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus   UniProt 18669648
S283 Phosphorylation PhosphoSitePlus   UniProt 18669648
T315 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus 9655255
Y451 Phosphorylation P12931 (SRC) PhosphoSitePlus 9655255
Y453 Phosphorylation PhosphoSitePlus 9655255
Y453 Phosphorylation P12931 (SRC) PhosphoSitePlus 9655255
Y483 Phosphorylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
Y491 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
Y501 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y553 Phosphorylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus   UniProt 18669648
S665 Phosphorylation PhosphoSitePlus   UniProt 18669648
S668 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
T675 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus   UniProt 18669648
S682 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
T686 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus   UniProt 18669648
T689 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
T730 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y93 Phosphorylation HPRD 9655255
Y93 Phosphorylation P12931 (SRC) HPRD 9655255
Y94 Phosphorylation HPRD 9655255
Y94 Phosphorylation P12931 (SRC) HPRD 9655255
T220 Phosphorylation HPRD 20068231
S264 Phosphorylation HPRD 20068231
S265 Phosphorylation HPRD 18669648, 17081983
S277 Phosphorylation HPRD 18669648, 15345747, 20068231
S278 Phosphorylation HPRD 18669648, 17081983, 20068231
S282 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S283 Phosphorylation HPRD 18669648, 15345747, 20068231
T315 Phosphorylation HPRD 20068231
S336 Phosphorylation HPRD 18669648, 17081983, 20068231
T337 Phosphorylation HPRD 18669648, 17081983
T341 Phosphorylation HPRD 18669648, 17081983
S342 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S343 Phosphorylation HPRD 18669648, 17081983, 18452278
S360 Phosphorylation HPRD 20068231
Y451 Phosphorylation HPRD 9655255
Y451 Phosphorylation P12931 (SRC) HPRD 9655255
Y453 Phosphorylation HPRD 9655255
Y453 Phosphorylation P12931 (SRC) HPRD 9655255
T546 Phosphorylation HPRD 20068231
S548 Phosphorylation HPRD 18212344, 20068231
T663 Phosphorylation HPRD 18669648
S664 Phosphorylation HPRD 18669648
S665 Phosphorylation HPRD 18669648, 19691289, 16565220
S668 Phosphorylation HPRD 18212344, 18767875, 19664994, ...19664995, 16565220, 18669648, 19415658, 20068231, 19691289
S679 Phosphorylation HPRD 18669648
S682 Phosphorylation HPRD 18669648
S683 Phosphorylation HPRD 18669648
T686 Phosphorylation HPRD 18669648
S687 Phosphorylation HPRD 19413330, 18669648, 20068231
S710 Phosphorylation HPRD 19664995, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y537 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 N47 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K47 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y94 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S101 R101 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S257 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S282 C282 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T315 S315 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S336 C336 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T341 N341 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S342 F342 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y353 C353 Biomuta DOID:1324 / lung cancer [ cosmic ]
S360 G360 Biomuta DOID:1324 / lung cancer [ cosmic ]
S360 N360 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T497 A497 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S510 L510 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S520 F520 Biomuta DOID:4159 / skin cancer [ cosmic ]
T546 M546 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S668 F668 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S668 Y668 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S668 P668 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S679 A679 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S679 L679 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S683 R683 Biomuta DOID:3571 / liver cancer [ cosmic ]
T689 I689 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S704 N704 Biomuta [ cosmic ]
S711 F711 Biomuta DOID:4159 / skin cancer [ cosmic ]
T730 S730 Biomuta DOID:1319 / brain cancer [ cosmic ]