iPTMnet Report for Q8N4X5 (AFAP1L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N4X5 / AF1L2_HUMAN
Protein Name Actin filament-associated protein 1-like 2
Gene Name Name: AFAP1L2
Synonyms:KIAA1914,XB130;
Organism Homo sapiens (Human)

PRO ID PR:Q8N4X5
DAG View
PRO Name actin filament-associated protein 1-like 2 (human)
Definition An actin filament-associated protein 1-like 2 that is encoded in the genome of human.
Short Label hAFAP1L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N4X5 (AFAP1L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation P07949 (RET) neXtProt   PhosphoSitePlus   Signor 19060924
Y56 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
K332 Methylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S397 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
Y413 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 15951569
S414 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
T456 Phosphorylation PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
Y459 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
S484 Phosphorylation IEDB   PhosphoSitePlus 30784271
Y489 Phosphorylation PhosphoSitePlus
Y537 Phosphorylation PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
K697 Acetylation PhosphoSitePlus
T761 O-Glycosylation GlyGen 30379171, 29351928
S767 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
T788 Phosphorylation PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y383 Phosphorylation HPRD 18083107
Y413 Phosphorylation HPRD 17016520, 15951569
T541 Phosphorylation HPRD 19664994
Y668 Phosphorylation HPRD 17924679
T669 Phosphorylation HPRD 17924679
Site PTM Type PTM Enzyme Score Source PMID
Y383 Phosphorylation HPRD 18083107
Y413 Phosphorylation HPRD 17016520, 15951569
T541 Phosphorylation HPRD 19664994
Y668 Phosphorylation HPRD 17924679
T669 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y56 N56 Biomuta DOID:3571 / liver cancer [ cosmic ]
T61 N61 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y161 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T284 I284 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S303 P303 Biomuta DOID:363 / uterine cancer [ icgc ]
S303 L303 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S334 I334 Biomuta DOID:4159 / skin cancer [ cosmic ]
S344 Y344 Biomuta DOID:3571 / liver cancer [ cosmic ]
S344 F344 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y413 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S414 F414 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S432 F432 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y459 H459 Biomuta DOID:4159 / skin cancer [ cosmic ]
K697 N697 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S796 L796 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]