iPTMnet Report for Q8N3U4 (STAG2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N3U4 / STAG2_HUMAN
Protein Name Cohesin subunit SA-2
Gene Name Name: STAG2
Synonyms:SA2;
Organism Homo sapiens (Human)

PRO ID PR:Q8N3U4
DAG View
PRO Name cohesin subunit SA-2 (human)
Definition A cohesin subunit SA-2 that is encoded in the genome of human.
Short Label hSTAG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N3U4 (STAG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Sumoylation PRO
M1 Acetylation UniProt 20068231
T25 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
C410 Methylation IEDB 31844290
Y433 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
C487 Methylation IEDB 31844290
K562 Ubiquitination PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
K607 Acetylation PhosphoSitePlus   UniProt 19608861
K607 Ubiquitination PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
C640 Methylation IEDB 31844290
K664 Ubiquitination PhosphoSitePlus
Y685 Phosphorylation PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
T737 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T749 Phosphorylation PhosphoSitePlus
S751 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S752 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K755 Ubiquitination PhosphoSitePlus
S843 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K860 Ubiquitination PhosphoSitePlus
C869 Methylation IEDB 31844290
Y892 Phosphorylation PhosphoSitePlus
Y893 Phosphorylation PhosphoSitePlus
Y896 Phosphorylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
K912 Ubiquitination PhosphoSitePlus
C915 Methylation IEDB 31844290
K949 Ubiquitination PhosphoSitePlus
K965 Ubiquitination PhosphoSitePlus
S1047 Phosphorylation PhosphoSitePlus
T1056 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1058 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S1061 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231
S1064 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1065 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R1066 Methylation PhosphoSitePlus
R1071 Methylation PhosphoSitePlus
S1091 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T1109 Phosphorylation PhosphoSitePlus
T1112 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 19690332
T1118 Phosphorylation PhosphoSitePlus
T1124 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1137 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1140 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
Y1142 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T1146 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T1151 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
R1158 Methylation PhosphoSitePlus
T1160 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1177 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1178 Phosphorylation PhosphoSitePlus   UniProt 20068231
T1193 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
S1224 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1229 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 20068231
S23 Phosphorylation HPRD 20068231
T25 Phosphorylation HPRD 20068231
S843 Phosphorylation HPRD 18452278
T1056 Phosphorylation HPRD 18669648
S1058 Phosphorylation HPRD 18669648, 20068231
S1061 Phosphorylation HPRD 18669648, 18452278, 19664995, ...20068231, 17081983
S1064 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S1065 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T1112 Phosphorylation HPRD 20068231
T1160 Phosphorylation HPRD 18669648, 20068231
S1161 Phosphorylation HPRD 20068231
S1177 Phosphorylation HPRD 20068231, 18452278
S1178 Phosphorylation HPRD 19651622, 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 20068231
S23 Phosphorylation HPRD 20068231
T25 Phosphorylation HPRD 20068231
S843 Phosphorylation HPRD 18452278
T1056 Phosphorylation HPRD 18669648
S1058 Phosphorylation HPRD 18669648, 20068231
S1061 Phosphorylation HPRD 18669648, 18452278, 19664995, ...20068231, 17081983
S1064 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S1065 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
T1112 Phosphorylation HPRD 20068231
T1197 Phosphorylation HPRD 18669648, 20068231
S1198 Phosphorylation HPRD 20068231
S1214 Phosphorylation HPRD 20068231, 18452278
S1215 Phosphorylation HPRD 19651622, 20068231, 18452278


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049359 (hSTAG2/PhosRes+) p PRO
PR:000049360 (hSTAG2/SumoLys+) su PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 F23 Biomuta DOID:1319 / brain cancer [ cosmic ]
T25 S25 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S173 Y173 Biomuta DOID:1612 / breast cancer [ cosmic ]
K358 E358 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K358 N358 Biomuta DOID:363 / uterine cancer [ icgc ]
K607 N607 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K664 R664 Biomuta DOID:363 / uterine cancer [ cosmic ]
K664 T664 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y685 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K705 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S751 R751 Biomuta DOID:1324 / lung cancer [ cosmic ]
C869 R869 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y892 C892 Biomuta DOID:363 / uterine cancer [ icgc ]
K901 E901 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K912 T912 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K949 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K949 N949 Biomuta DOID:4159 / skin cancer [ cosmic ] [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, cosmic ]
T1056 I1056 Biomuta [ cosmic ]
S1058 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1058 L1058 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1065 R1065 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1065 N1065 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R1066 W1066 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1066 Q1066 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1071 W1071 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R1071 Q1071 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y1142 C1142 Biomuta DOID:363 / uterine cancer [ icgc ]
T1151 I1151 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1151 K1151 Biomuta [ cosmic ]
R1158 C1158 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R1158 H1158 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1161 R1161 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1177 P1177 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1178 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1178 L1178 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S1198 R1198 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1214 P1214 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1215 L1215 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1215 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1219 L1219 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1229 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1229 L1229 Biomuta DOID:2531 / hematologic cancer [ cosmic ]