Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N3J2 / METL4_HUMAN
Protein Name N(6)-adenine-specific DNA methyltransferase METTL4
Gene Name Name: METTL4
Organism Homo sapiens (Human)

PRO ID PR:Q8N3J2
DAG View
PRO Name methyltransferase-like protein 4 (human)
Definition A methyltransferase-like protein 4 that is encoded in the genome of human.
Short Label hMETTL4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N3J2 (METTL4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S55 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S55 F55 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S362 L362 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K388 * Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]