iPTMnet Report for Q8N3J2 (METTL4)
Protein Information
| UniProt AC / UniProt ID | Q8N3J2 / METL4_HUMAN |
| Protein Name | N(6)-adenine-specific methyltransferase METTL4 |
| Gene Name | Name: METTL4 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8N3J2 |
| PRO Name | N(6)-adenine-specific methyltransferase METTL4 (human) |
| Definition | An N(6)-adenine-specific methyltransferase METTL4 that is encoded in the genome of human. |
| Short Label | hMETTL4 |
| Category | organism-gene |
DAG ViewQ8N3J2 (METTL4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K132 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y255 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S266 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T360 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S362 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S371 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y377 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K388 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K432 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S55 | F55 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K132 | N132 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S362 | L362 | Biomuta | DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
| K388 | * | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
