iPTMnet Report for Q8N3E9 (PLCD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N3E9 / PLCD3_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
Gene Name Name: PLCD3
Synonyms:KIAA1964;
Organism Homo sapiens (Human)

PRO ID PR:Q8N3E9
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 that is encoded in the genome of human.
Short Label hPLCD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N3E9 (PLCD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S105 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K148 Ubiquitination PhosphoSitePlus
S200 Phosphorylation HPRD   PhosphoSitePlus 20166139
K205 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
S496 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...18452278
Y534 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus   UniProt 23186163
T583 Phosphorylation PhosphoSitePlus
Y706 Phosphorylation PhosphoSitePlus
T742 Phosphorylation PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S105 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S200 N200 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y222 H222 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T583 N583 Biomuta DOID:3571 / liver cancer [ cosmic ]
T583 S583 Biomuta DOID:1324 / lung cancer [ cosmic ]