iPTMnet Report for Q8N3C0 (ASCC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N3C0 / ASCC3_HUMAN
Protein Name Activating signal cointegrator 1 complex subunit 3
Gene Name Name: ASCC3
Synonyms:HELIC1,RQT2;
Organism Homo sapiens (Human)

PRO ID PR:Q8N3C0
DAG View
PRO Name activating signal cointegrator 1 complex subunit 3 (human)
Definition An activating signal cointegrator 1 complex subunit 3 that is encoded in the genome of human.
Short Label hASCC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N3C0 (ASCC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus   UniProt 23186163
K18 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
R160 Methylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
C225 Methylation IEDB 31844290
T234 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
C366 Methylation IEDB 31844290
K370 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
T565 Phosphorylation PhosphoSitePlus
K572 Acetylation PhosphoSitePlus   UniProt 19608861
K572 Ubiquitination PhosphoSitePlus
T578 Phosphorylation PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
T592 Phosphorylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
T631 Phosphorylation IEDB 29493099
S637 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
K740 Ubiquitination PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
K834 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
T973 Phosphorylation PhosphoSitePlus
Y975 Phosphorylation PhosphoSitePlus
K1006 Ubiquitination PhosphoSitePlus
K1017 Ubiquitination PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
T1104 Phosphorylation PhosphoSitePlus
T1106 Phosphorylation PhosphoSitePlus
Y1107 Phosphorylation PhosphoSitePlus
S1131 Phosphorylation PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
T1256 Phosphorylation IEDB 32387766
C1343 Methylation IEDB 31844290
K1369 Ubiquitination PhosphoSitePlus
K1374 Ubiquitination PhosphoSitePlus
K1382 Methylation PhosphoSitePlus
K1382 Ubiquitination PhosphoSitePlus
K1399 Acetylation PhosphoSitePlus
K1399 Ubiquitination PhosphoSitePlus
K1403 Acetylation PhosphoSitePlus
K1403 Ubiquitination PhosphoSitePlus
K1416 Ubiquitination PhosphoSitePlus
K1420 Ubiquitination PhosphoSitePlus
K1430 Ubiquitination PhosphoSitePlus
T1480 Phosphorylation PhosphoSitePlus
K1482 Ubiquitination PhosphoSitePlus
S1490 Phosphorylation PhosphoSitePlus
T1491 Phosphorylation PhosphoSitePlus
S1540 Phosphorylation PhosphoSitePlus
K1543 Ubiquitination PhosphoSitePlus
S1551 Phosphorylation PhosphoSitePlus
S1553 Phosphorylation PhosphoSitePlus
S1563 Phosphorylation PhosphoSitePlus
S1606 Phosphorylation PhosphoSitePlus
K1609 Methylation PhosphoSitePlus
T1611 Phosphorylation PhosphoSitePlus
K1671 Ubiquitination PhosphoSitePlus
K1700 Ubiquitination PhosphoSitePlus
K1709 Acetylation PhosphoSitePlus
K1709 Ubiquitination PhosphoSitePlus
K1715 Sumoylation PhosphoSitePlus
T1745 Phosphorylation PhosphoSitePlus
S1746 Phosphorylation PhosphoSitePlus
K1825 Methylation PhosphoSitePlus
K1830 Ubiquitination PhosphoSitePlus
K1837 Ubiquitination PhosphoSitePlus
K1873 Ubiquitination PhosphoSitePlus
Y1909 Phosphorylation PhosphoSitePlus
T1915 Phosphorylation PhosphoSitePlus
K1976 Ubiquitination PhosphoSitePlus
K1983 Ubiquitination PhosphoSitePlus
K2022 Ubiquitination PhosphoSitePlus
K2065 Ubiquitination PhosphoSitePlus
K2070 Ubiquitination PhosphoSitePlus
K2097 Ubiquitination PhosphoSitePlus
K2111 Ubiquitination PhosphoSitePlus
S2195 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
T565 Phosphorylation HPRD 19651622
S595 Phosphorylation HPRD 20068231
S1551 Phosphorylation HPRD 20068231
S1553 Phosphorylation HPRD 20068231
S1563 Phosphorylation HPRD 20068231
T1915 Phosphorylation HPRD 20068231
S2195 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 F12 Biomuta DOID:4159 / skin cancer [ cosmic ]
K30 N30 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K52 N52 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R160 M160 Biomuta DOID:1319 / brain cancer [ cosmic ]
S170 L170 Biomuta DOID:4159 / skin cancer [ cosmic ]
S170 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S221 F221 Biomuta DOID:4159 / skin cancer [ cosmic ]
T234 A234 Biomuta DOID:1324 / lung cancer [ cosmic ]
S298 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K312 T312 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K312 N312 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K572 T572 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T584 P584 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S640 I640 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K860 I860 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1104 I1104 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1369 E1369 Biomuta DOID:363 / uterine cancer [ icgc ]
K1416 I1416 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1480 A1480 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S1540 N1540 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1609 E1609 Biomuta DOID:1612 / breast cancer [ icgc ]
T1611 A1611 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1611 I1611 Biomuta [ cosmic ]
K1671 R1671 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1909 C1909 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1983 R1983 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K2097 N2097 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S2195 T2195 Biomuta DOID:4159 / skin cancer [ cosmic ]