iPTMnet Report for Q8N3A8 (PARP8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N3A8 / PARP8_HUMAN
Protein Name Protein mono-ADP-ribosyltransferase PARP8
Gene Name Name: PARP8
Organism Homo sapiens (Human)

PRO ID PR:Q8N3A8
DAG View
PRO Name protein mono-ADP-ribosyltransferase PARP8 (human)
Definition A protein mono-ADP-ribosyltransferase PARP8 that is encoded in the genome of human.
Short Label hPARP8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N3A8 (PARP8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K20 Ubiquitination PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K257 Acetylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K372 Acetylation PhosphoSitePlus
K372 Sumoylation PhosphoSitePlus
K380 Acetylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
K405 Acetylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
S760 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T767 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S770 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Site PTM Type PTM Enzyme Score Source PMID
S760 Phosphorylation HPRD 17525332
T767 Phosphorylation HPRD 17525332
S770 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K257 R257 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S284 F284 Biomuta DOID:1324 / lung cancer [ cosmic ]
S284 C284 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T285 I285 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S289 L289 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S323 F323 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K358 Q358 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S412 C412 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K431 R431 Biomuta DOID:4159 / skin cancer [ cosmic ]
S760 L760 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T767 A767 Biomuta DOID:1319 / brain cancer [ icgc ]
S770 P770 Biomuta DOID:9256 / colorectal cancer [ cosmic ]