iPTMnet Report for Q8N392 (ARHGAP18)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N392 / RHG18_HUMAN
Protein Name Rho GTPase-activating protein 18
Gene Name Name: ARHGAP18
Organism Homo sapiens (Human)

PRO ID PR:Q8N392
DAG View
PRO Name Rho GTPase-activating protein 18 (human)
Definition A Rho GTPase-activating protein 18 that is encoded in the genome of human.
Short Label hARHGAP18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N392 (ARHGAP18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus   RLIMS-P 33092266
S156 Phosphorylation RLIMS-P 33092266
T158 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33092266, 23186163
S209 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus   UniProt 23186163
K310 Acetylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus   UniProt 23186163
K620 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation HPRD 18077418
S69 Phosphorylation HPRD 18077418
S610 Phosphorylation HPRD 18077418


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8N392 (ARHGAP18) T154 Q6P5Z2 (PKN3) unknown eFIP 33092266


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y44 C44 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S66 F66 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T154 K154 Biomuta DOID:3571 / liver cancer [ cosmic ]
T431 I431 Biomuta DOID:4159 / skin cancer [ cosmic ]
K432 Q432 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K432 M432 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K520 Q520 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S587 L587 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc ]
S610 R610 Biomuta DOID:3571 / liver cancer [ cosmic ]