Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N2W9 / PIAS4_HUMAN
Protein Name E3 SUMO-protein ligase PIAS4
Gene Name Name: PIAS4
Synonyms:PIASG;
Organism Homo sapiens (Human)

PRO ID PR:Q8N2W9
DAG View
PRO Name E3 SUMO-protein ligase PIAS4 (human)
Definition An E3 SUMO-protein ligase PIAS4 that is encoded in the genome of human.
Short Label hPIAS4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N2W9 (PIAS4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K9 Sumoylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K35 Sumoylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K59 Sumoylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K69 Sumoylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K114 Acetylation PhosphoSitePlus   UniProt 19608861
K114 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K135 Sumoylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K231 Sumoylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation HPRD   PhosphoSitePlus 19413330
K294 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K306 Sumoylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus


Q8N2W9 (PIAS4) as PTM Enzyme



Substrate Site Score Source PMID
P15927 (RPA2) S4 Signor 20016603
P15927 (RPA2) S8 Signor 20016603


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 E56 Biomuta DOID:363 / uterine cancer [ tcga ]
Y108 C108 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K158 T158 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K231 N231 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K306 N306 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]