iPTMnet Report for Q8N1W1 (ARHGEF28)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N1W1 / ARG28_HUMAN
Protein Name Rho guanine nucleotide exchange factor 28
Gene Name Name: ARHGEF28
Synonyms:KIAA1998,RGNEF;
Organism Homo sapiens (Human)

PRO ID PR:Q8N1W1
DAG View
PRO Name Rho guanine nucleotide exchange factor 28 (human)
Definition A Rho guanine nucleotide exchange factor 28 that is encoded in the genome of human.
Short Label hARHGEF28
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N1W1 (ARHGEF28) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
K611 Acetylation PhosphoSitePlus
K616 Acetylation PhosphoSitePlus
K618 Acetylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus   UniProt 18669648
K693 Acetylation PhosphoSitePlus
T700 Phosphorylation PhosphoSitePlus
K706 Acetylation PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
T748 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
Y1006 Phosphorylation PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
Y1124 Phosphorylation PhosphoSitePlus
K1194 Ubiquitination PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
T1312 Phosphorylation PhosphoSitePlus
S1314 Phosphorylation PhosphoSitePlus
S1315 Phosphorylation PhosphoSitePlus
S1321 Phosphorylation PhosphoSitePlus
T1323 Phosphorylation PhosphoSitePlus
S1481 Phosphorylation PhosphoSitePlus
S1538 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1558 Phosphorylation PhosphoSitePlus
S1598 Phosphorylation PhosphoSitePlus
S1600 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y11 L11 Biomuta DOID:4159 / skin cancer [ cosmic ]
S558 F558 Biomuta DOID:4159 / skin cancer [ cosmic ]
S590 L590 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S624 N624 Biomuta DOID:4159 / skin cancer [ cosmic ]
K693 E693 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1481 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1598 C1598 Biomuta DOID:10283 / prostate cancer [ cosmic ]