iPTMnet Report for Q8N1G2 (CMTR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N1G2 / CMTR1_HUMAN
Protein Name Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Gene Name Name: CMTR1
Synonyms:FTSJD2,KIAA0082,MTR1;
Organism Homo sapiens (Human)

PRO ID PR:Q8N1G2
DAG View
PRO Name cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (human)
Definition A cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 that is encoded in the genome of human.
Short Label hCMTR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N1G2 (CMTR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
T5 O-Glycosylation GlyGen 34019948, 30620550
S26 Phosphorylation PhosphoSitePlus
S28 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S29 Phosphorylation PhosphoSitePlus
T30 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S31 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S49 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S51 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 19651622, ...18669648, 24275569, 20068231
S55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17081983, 19651622, ...18669648, 20068231
T57 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S63 Phosphorylation HPRD   PhosphoSitePlus 17081983
S64 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 17081983
S66 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983
K72 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus   UniProt 23186163
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K108 Acetylation PhosphoSitePlus   UniProt 19608861
K108 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
Y224 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K239 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
C403 Methylation IEDB 31844290
T405 Phosphorylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
R537 Methylation PhosphoSitePlus
S550 Phosphorylation HPRD 20068231
K555 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
S694 Phosphorylation HPRD   PhosphoSitePlus 19664995
K704 Ubiquitination PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
C794 Methylation IEDB 31844290
K823 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R4 I4 Biomuta DOID:3571 / liver cancer [ cosmic ]
S55 G55 Biomuta DOID:3571 / liver cancer [ cosmic ]
S66 F66 Biomuta DOID:4159 / skin cancer [ cosmic ]
S75 Y75 Biomuta DOID:363 / uterine cancer [ icgc ]
S75 F75 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S85 F85 Biomuta DOID:4159 / skin cancer [ cosmic ]
S89 I89 Biomuta DOID:1324 / lung cancer [ cosmic ]
S89 C89 Biomuta DOID:1324 / lung cancer [ cosmic ]
S91 P91 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S110 R110 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y224 C224 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T405 I405 Biomuta DOID:4159 / skin cancer [ cosmic ]
K714 N714 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K777 N777 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C794 F794 Biomuta DOID:1324 / lung cancer [ cosmic ]
C794 S794 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]