iPTMnet Report for Q8N122 (RPTOR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N122 / RPTOR_HUMAN
Protein Name Regulatory-associated protein of mTOR
Gene Name Name: RPTOR
Synonyms:KIAA1303;
Organism Homo sapiens (Human)

PRO ID PR:Q8N122
DAG View
PRO Name regulatory-associated protein of mTOR (human)
Definition A regulatory-associated protein of mTOR that is encoded in the genome of human.
Short Label hRPTOR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N122 (RPTOR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21071439
K43 Ubiquitination PhosphoSitePlus
S44 Phosphorylation RLIMS-P   UniProt 31530866
S48 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S122 Phosphorylation RLIMS-P   UniProt 31530866
K131 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus   RLIMS-P 32015438
Y692 Phosphorylation PhosphoSitePlus
S696 Phosphorylation P45983 (MAPK8) , P28482 (MAPK1) , P06493 (CDK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20169205, 23186163, 19864431, ...22493283, 21325048, 31530866, 21071439
T699 Phosphorylation PhosphoSitePlus
T700 O-Glycosylation GlyGen 32938750, 30379171, 34725712, ...35254053, 29485866, 28657654
T700 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
T706 Phosphorylation P06493 (CDK1) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31530866, 22493283, 20169205, ...19864431
S711 Phosphorylation PhosphoSitePlus   RLIMS-P 20169205
T714 Phosphorylation PhosphoSitePlus
R716 Methylation PhosphoSitePlus
R718 Methylation PhosphoSitePlus
S719 Phosphorylation Q15418 (RPS6KA1) , P51812 (RPS6KA3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 18220336, 18669648, ...19276368, 18722121
S721 Phosphorylation P51812 (RPS6KA3) , Q15418 (RPS6KA1) , Q9UIK4 (DAPK2) neXtProt   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 25361081, 18722121
S722 Phosphorylation P51812 (RPS6KA3) , Q15418 (RPS6KA1) , Q13131 (PRKAA1) , P49841 (GSK3B) IEDB   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26397365, 23186163, 26348909, ...18220336, 34604061, 27920218, 18669648, 19276368, 18439900, 21325048, 18722121
Y723 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S738 Phosphorylation PhosphoSitePlus   UniProt 24275569
S771 Phosphorylation Q15759 (MAPK11) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21757713
S791 Phosphorylation PhosphoSitePlus   UniProt 31112131
S792 Phosphorylation O75385 (ULK1) , P49841 (GSK3B) , Q13131 (PRKAA1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 26397365, 30771309, 18439900, ...34604061, 20019839, 25761126, 20639120, 21460630, 26348909
S795 Phosphorylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31530866
K840 Ubiquitination PhosphoSitePlus
T853 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S854 Phosphorylation PhosphoSitePlus
S855 Phosphorylation O75385 (ULK1) , P42345 (MTOR) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19864431, 18669648, 25761126, ...21325048, 21460630
T857 Phosphorylation PhosphoSitePlus
S859 Phosphorylation O75385 (ULK1) , P42345 (MTOR) , P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 17081983, 19346248, ...19864431, 18669648, 20068231, 25761126, 31530866, 19690332, 21460630, 26348909
S863 Phosphorylation P42345 (MTOR) , Q15759 (MAPK11) , P27361 (MAPK3) , P49841 (GSK3B) , P28482 (MAPK1) , P45983 (MAPK8) , Q9UBE8 (NLK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16964243, 15302935, 22493283, ...21071439, 21406692, 23186163, 21757713, 26588989, 25153728, 24813396, 19690332, 19346248, 31530866, 17081983, 20169205, 26348909, 27043084, 19864431, 18669648, 21325048, 20068231
T865 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 21325048, 23186163
K867 Ubiquitination PhosphoSitePlus
S877 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 20169205, ...23186163, 26348909, 19369195, 19864431, 18669648, 24275569, 26588989, 31530866, 19690332, 20068231
S881 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S882 Phosphorylation PhosphoSitePlus
T883 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S884 Phosphorylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
T889 Phosphorylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
T908 Phosphorylation Q9UPZ9 (CILK1) PhosphoSitePlus   RLIMS-P   Signor 22356909
Y916 Phosphorylation PhosphoSitePlus
T917 Phosphorylation PhosphoSitePlus
K932 Ubiquitination UniProt 35927303
K948 Ubiquitination UniProt 35927303
K973 Ubiquitination PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31530866
K1008 Ubiquitination PhosphoSitePlus
K1030 Ubiquitination PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
K1056 Ubiquitination PhosphoSitePlus
K1097 Acetylation PhosphoSitePlus   UniProt 32561715, 30197302
K1097 Ubiquitination PhosphoSitePlus
K1157 Ubiquitination PhosphoSitePlus
S1189 O-Glycosylation GlyGen 29485866, 30379171, 34725712, ...28657654, 35254053
S1189 Phosphorylation PhosphoSitePlus
Y1193 Phosphorylation PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S719 Phosphorylation HPRD 18669648
S722 Phosphorylation HPRD 19413330, 18767875, 18669648
Y723 Phosphorylation HPRD 18669648
T853 Phosphorylation HPRD 18669648, 20068231
S855 Phosphorylation HPRD 18669648
T857 Phosphorylation HPRD 19664995, 19415658, 20068231, ...20230923
S859 Phosphorylation HPRD 19413330, 18691976, 17081983, ...20230923, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
S863 Phosphorylation HPRD 19413330, 18691976, 18491316, ...16964243, 20230923, 19664994, 20058876, 19664995, 18452278, 19651622, 15302935, 18669648, 20166139, 19415658, 20068231
T865 Phosphorylation HPRD 18767875, 18669648, 19415658, ...20068231, 20230923
S877 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19651622, 20068231
S881 Phosphorylation HPRD 18669648
T883 Phosphorylation HPRD 18669648
S884 Phosphorylation HPRD 17081983


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049138 (hRPTOR/Phos:2) pS722,pS792 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8N122 (RPTOR) S606 Q15382 (RHEB) inhibited_association eFIP 32015438
Phosphorylation Q8N122 (RPTOR) S859 Q68ED7 (Crtc1) decreased_association eFIP 30397197


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 C44 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K132 Q132 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K207 N207 Biomuta DOID:1324 / lung cancer [ cosmic ]
K335 N335 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S606 I606 Biomuta DOID:3571 / liver cancer [ cosmic ]
S696 Y696 Biomuta DOID:363 / uterine cancer [ cosmic ]
R718 C718 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S719 F719 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S719 Y719 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S721 N721 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y723 C723 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S738 Y738 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S792 F792 Biomuta [ cosmic ]
S854 A854 Biomuta DOID:184 / bone cancer [ cosmic ]
S855 Y855 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T857 M857 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ]
K867 R867 Biomuta DOID:1324 / lung cancer [ cosmic ]
S877 F877 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
T889 A889 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y916 C916 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T917 I917 Biomuta DOID:1612 / breast cancer [ cosmic ]
K948 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K973 M973 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]