iPTMnet Report for Q8N108 (MIER1)
Protein Information
| UniProt AC / UniProt ID | Q8N108 / MIER1_HUMAN |
| Protein Name | Mesoderm induction early response protein 1 |
| Gene Name | Name: MIER1 Synonyms:KIAA1610; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8N108 |
| PRO Name | mesoderm induction early response protein 1 (human) |
| Definition | A mesoderm induction early response protein 1 that is encoded in the genome of human. |
| Short Label | hMIER1 |
| Category | organism-gene |
DAG ViewQ8N108 (MIER1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S10 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| T38 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S52 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S53 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S71 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S77 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| S121 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S122 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S130 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S131 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S141 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| Y155 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648 | ||
| T158 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S160 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 21406692, 19690332 | ||
| S166 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 21406692, 20068231, ... | ||
| Y172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C197 | Methylation | score1 | IEDB | 31844290 | ||
| K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K239 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K251 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y258 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K262 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K301 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S367 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S369 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S373 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S377 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
| T381 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S383 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S407 | Phosphorylation | score1 | phospho.ELM | 15302935 | ||
| K420 | Sumoylation | score1 | PhosphoSitePlus | |||
| T448 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S483 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 23186163, 21406692, ... | ||
| S488 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 23186163, 21406692, ... | ||
| S491 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S492 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T510 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S52 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S53 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S121 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S122 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| T128 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S130 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S131 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S141 | Phosphorylation | score0 | HPRD | 18077418 | ||
| Y155 | Phosphorylation | score0 | HPRD | 18669648, 17081983 | ||
| T158 | Phosphorylation | score0 | HPRD | 18669648, 20068231, 18452278 | ||
| S160 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 18452278, ... | ||
| S166 | Phosphorylation | score0 | HPRD | 19413330, 18452278, 19651622, ... | ||
| S367 | Phosphorylation | score0 | HPRD | 19691289, 20068231 | ||
| S369 | Phosphorylation | score0 | HPRD | 17081983, 20068231, 19691289 | ||
| S372 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S373 | Phosphorylation | score0 | HPRD | 19007248 | ||
| S377 | Phosphorylation | score0 | HPRD | 19664994, 19691289, 20068231 | ||
| S483 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
| S488 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983, ... | ||
| S491 | Phosphorylation | score0 | HPRD | 19651622, 20068231 | ||
| S492 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S500 | Phosphorylation | score0 | HPRD | 17081983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S105 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S106 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S174 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S175 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| T181 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S183 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S184 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S194 | Phosphorylation | score0 | HPRD | 18077418 | ||
| Y208 | Phosphorylation | score0 | HPRD | 18669648, 17081983 | ||
| T211 | Phosphorylation | score0 | HPRD | 18669648, 20068231, 18452278 | ||
| S213 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 18452278, ... | ||
| S219 | Phosphorylation | score0 | HPRD | 19413330, 18452278, 19651622, ... | ||
| S420 | Phosphorylation | score0 | HPRD | 19691289, 20068231 | ||
| S422 | Phosphorylation | score0 | HPRD | 17081983, 20068231, 19691289 | ||
| S425 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S426 | Phosphorylation | score0 | HPRD | 19007248 | ||
| S430 | Phosphorylation | score0 | HPRD | 19664994, 19691289, 20068231 | ||
| S536 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
| S541 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983, ... | ||
| S544 | Phosphorylation | score0 | HPRD | 19651622, 20068231 | ||
| S545 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S553 | Phosphorylation | score0 | HPRD | 17081983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S69 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S70 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S138 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S139 | Phosphorylation | score0 | HPRD | 15302935, 18452278 | ||
| S147 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S148 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S158 | Phosphorylation | score0 | HPRD | 18077418 | ||
| Y172 | Phosphorylation | score0 | HPRD | 18669648, 17081983 | ||
| T175 | Phosphorylation | score0 | HPRD | 18669648, 20068231, 18452278 | ||
| S177 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 18452278, ... | ||
| S183 | Phosphorylation | score0 | HPRD | 19413330, 15302935, 18452278, ... | ||
| S384 | Phosphorylation | score0 | HPRD | 19691289, 20068231 | ||
| S386 | Phosphorylation | score0 | HPRD | 17081983, 20068231, 19691289 | ||
| S389 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S390 | Phosphorylation | score0 | HPRD | 19007248 | ||
| S394 | Phosphorylation | score0 | HPRD | 15302935, 19664994, 19691289, ... | ||
| T398 | Phosphorylation | score0 | HPRD | 15302935 | ||
| S400 | Phosphorylation | score0 | HPRD | 15302935 | ||
| S500 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231, ... | ||
| S505 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231, ... | ||
| S508 | Phosphorylation | score0 | HPRD | 19651622, 20068231 | ||
| S509 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S517 | Phosphorylation | score0 | HPRD | 17081983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S69 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S70 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S138 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S139 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S147 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S148 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S158 | Phosphorylation | score0 | HPRD | 18077418 | ||
| Y172 | Phosphorylation | score0 | HPRD | 18669648, 17081983 | ||
| T175 | Phosphorylation | score0 | HPRD | 18669648, 20068231, 18452278 | ||
| S177 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 18452278, ... | ||
| S183 | Phosphorylation | score0 | HPRD | 19413330, 18452278, 19651622, ... | ||
| S384 | Phosphorylation | score0 | HPRD | 19691289, 20068231 | ||
| S386 | Phosphorylation | score0 | HPRD | 17081983, 20068231, 19691289 | ||
| S389 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S390 | Phosphorylation | score0 | HPRD | 19007248 | ||
| S394 | Phosphorylation | score0 | HPRD | 19664994, 19691289, 20068231 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S105 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S106 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S174 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S175 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| T181 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S183 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S184 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S194 | Phosphorylation | score0 | HPRD | 18077418 | ||
| Y208 | Phosphorylation | score0 | HPRD | 18669648, 17081983 | ||
| T211 | Phosphorylation | score0 | HPRD | 18669648, 20068231, 18452278 | ||
| S213 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 18452278, ... | ||
| S219 | Phosphorylation | score0 | HPRD | 19413330, 18452278, 19651622, ... | ||
| S420 | Phosphorylation | score0 | HPRD | 19691289, 20068231 | ||
| S422 | Phosphorylation | score0 | HPRD | 17081983, 20068231, 19691289 | ||
| S425 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S426 | Phosphorylation | score0 | HPRD | 19007248 | ||
| S430 | Phosphorylation | score0 | HPRD | 19664994, 19691289, 20068231 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S52 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S53 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S121 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S122 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| T128 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S130 | Phosphorylation | score0 | HPRD | 18452278 | ||
| S131 | Phosphorylation | score0 | HPRD | 17081983, 18452278 | ||
| S141 | Phosphorylation | score0 | HPRD | 18077418 | ||
| Y155 | Phosphorylation | score0 | HPRD | 18669648, 17081983 | ||
| T158 | Phosphorylation | score0 | HPRD | 18669648, 20068231, 18452278 | ||
| S160 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 18452278, ... | ||
| S166 | Phosphorylation | score0 | HPRD | 19413330, 18452278, 19651622, ... | ||
| S367 | Phosphorylation | score0 | HPRD | 19691289, 20068231 | ||
| S369 | Phosphorylation | score0 | HPRD | 17081983, 20068231, 19691289 | ||
| S372 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S373 | Phosphorylation | score0 | HPRD | 19007248 | ||
| S377 | Phosphorylation | score0 | HPRD | 19664994, 19691289, 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S10 | C10 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| T38 | A38 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S130 | F130 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S147 | F147 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| Y155 | D155 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| Y172 | D172 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc ] | |
| S183 | F183 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| Y208 | D208 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K251 | E251 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S407 | P407 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
