iPTMnet Report for Q8N0Z3 (SPICE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N0Z3 / SPICE_HUMAN
Protein Name Spindle and centriole-associated protein 1
Gene Name Name: SPICE1
Synonyms:CCDC52,SPICE;
Organism Homo sapiens (Human)

PRO ID PR:Q8N0Z3
DAG View
PRO Name spindle and centriole-associated protein 1 (human)
Definition A spindle and centriole-associated protein 1 that is encoded in the genome of human.
Short Label hSPICE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N0Z3 (SPICE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Acetylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
K29 Sumoylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
T45 Phosphorylation HPRD   PhosphoSitePlus 19691289
K71 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T84 Phosphorylation HPRD   PhosphoSitePlus 19651622
K89 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T235 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163
T239 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
T256 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
R472 Methylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
T537 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
S640 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 23186163
S644 Phosphorylation PhosphoSitePlus   UniProt 19690332
S680 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
S760 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 19690332, 20068231
S764 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
K778 Ubiquitination PhosphoSitePlus
R779 Methylation PhosphoSitePlus
S794 O-Glycosylation GlyGen 30379171, 30059200
K795 Ubiquitination PhosphoSitePlus
T798 Phosphorylation PhosphoSitePlus   RLIMS-P 30485161
S800 Phosphorylation HPRD   PhosphoSitePlus 19691289
R809 Methylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus   RLIMS-P 30485161
S817 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
T824 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
T831 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 N17 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T84 P84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S112 Y112 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S112 C112 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T239 M239 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K291 I291 Biomuta DOID:4362 / cervical cancer [ icgc ]
S315 L315 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
T318 I318 Biomuta DOID:3571 / liver cancer [ cosmic ]
T470 S470 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R472 G472 Biomuta DOID:1324 / lung cancer [ cosmic ]
K523 N523 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
K616 T616 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S680 L680 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S764 P764 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K795 T795 Biomuta DOID:9256 / colorectal cancer [ icgc ]