Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZP0 / ABI1_HUMAN
Protein Name Abl interactor 1
Gene Name Name: ABI1
Synonyms:SSH3BP1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZP0
DAG View
PRO Name Abl interactor 1 (human)
Definition An Abl interactor 1 that is encoded in the genome of human.
Short Label hABI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZP0 (ABI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
Y23 Phosphorylation PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
S88 Phosphorylation neXtProt   PhosphoSitePlus 22993434
S88 Phosphorylation Q9UQM7 (CAMK2A) neXtProt 22993434
K123 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus   UniProt 24275569
T178 Phosphorylation PhosphoSitePlus   UniProt 24275569
S183 Phosphorylation neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 18669648, 21419341, 23186163, ...24275569
S183 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 21419341
S183 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 21419341
S187 Phosphorylation PhosphoSitePlus   UniProt 24275569
T191 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
T200 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
Y213 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21320496, 18328268, 20598684, ...18083107, 26473374, 23186163, 32673396, 16497976
Y213 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 21320496, 18328268
T215 Phosphorylation PhosphoSitePlus
S216 Phosphorylation neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32673396, 18669648, 21419341, ...21900237
S216 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 21900237
S216 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 21419341
S216 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 21419341
S222 Phosphorylation PhosphoSitePlus   Signor   UniProt 21406692, 21419341, 24275569
S222 Phosphorylation P28482 (MAPK1) Signor 21419341
S225 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 18088087, ...17081983, 21419341, 24275569, 23186163, 20068231
S225 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 21419341
S225 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 21419341
T229 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T265 Phosphorylation neXtProt   PhosphoSitePlus 21419341
T265 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 21419341
T265 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 21419341
S267 Phosphorylation neXtProt   PhosphoSitePlus 21419341
S267 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 21419341
S267 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 21419341
S319 Phosphorylation PhosphoSitePlus   UniProt 23186163
S323 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T324 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
Y333 Phosphorylation phospho.ELM   PhosphoSitePlus 12522270
T336 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
Y355 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S392 Phosphorylation neXtProt   PRO   PhosphoSitePlus 21419341
S392 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 21419341
S392 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 21419341
T394 Phosphorylation neXtProt   PhosphoSitePlus 21419341
T394 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 21419341
T394 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 21419341
S410 Phosphorylation neXtProt   PRO   PhosphoSitePlus 21419341
S410 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 21419341
S410 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 21419341
Y421 Phosphorylation IntAct   PhosphoSitePlus 20598684
Y431 Phosphorylation PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus   RLIMS-P 24913355
Y455 Phosphorylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation IntAct   PhosphoSitePlus 20598684
T507 Phosphorylation PhosphoSitePlus   UniProt 20068231
Site PTM Type PTM Enzyme Score Source PMID
T178 Phosphorylation HPRD 19651622
S183 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18491316, 20068231
Y198 Phosphorylation HPRD 19901323, 16497976
T200 Phosphorylation HPRD 19901323
T208 Phosphorylation HPRD 19901323
Y213 Phosphorylation HPRD 19901323, 17389395, 18083107, ...18707149, 20068231, 16497976
T215 Phosphorylation HPRD 19901323, 18669648, 18707149
S216 Phosphorylation HPRD 18669648, 20068231
S222 Phosphorylation HPRD 19651622, 20068231
S225 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18707149, 20068231
S323 Phosphorylation HPRD 19651622
T507 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T104 Phosphorylation PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S241 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T178 Phosphorylation HPRD 19651622
S183 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18491316, 20068231
Y198 Phosphorylation HPRD 19901323, 16497976
T200 Phosphorylation HPRD 19901323
T208 Phosphorylation HPRD 19901323
Y213 Phosphorylation HPRD 19901323, 17389395, 18083107, ...18707149, 20068231, 16497976
T215 Phosphorylation HPRD 19901323, 18669648, 18707149
S216 Phosphorylation HPRD 18669648, 20068231
S222 Phosphorylation HPRD 19651622, 20068231
S225 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18707149, 20068231
T238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
S296 Phosphorylation HPRD 19651622
T451 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T173 Phosphorylation HPRD 19651622
S178 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18491316, 20068231
Y193 Phosphorylation HPRD 19901323, 16497976
T195 Phosphorylation HPRD 19901323
T203 Phosphorylation HPRD 19901323
Y208 Phosphorylation HPRD 19901323, 17389395, 18083107, ...18707149, 20068231, 16497976
T210 Phosphorylation HPRD 19901323, 18669648, 18707149
S211 Phosphorylation HPRD 18669648, 20068231
S217 Phosphorylation HPRD 19651622, 20068231
S220 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18707149, 20068231
S291 Phosphorylation HPRD 19651622
T475 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T178 Phosphorylation HPRD 19651622
S183 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18491316, 20068231
Y198 Phosphorylation HPRD 19901323, 16497976
T200 Phosphorylation HPRD 19901323
T208 Phosphorylation HPRD 19901323
Y213 Phosphorylation HPRD 19901323, 17389395, 18083107, ...18707149, 20068231, 16497976
T215 Phosphorylation HPRD 19901323, 18669648, 18707149
S216 Phosphorylation HPRD 18669648, 20068231
S222 Phosphorylation HPRD 19651622, 20068231
S225 Phosphorylation HPRD 18691976, 18088087, 17081983, ...19651622, 18707149, 20068231
S296 Phosphorylation HPRD 19651622
T480 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046224 (hABI1/InitMet-/Phos:2) pS183,pS216,pS225,pS392,pS410 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8IZP0 (ABI1) Y213 P00519 (ABL1) unknown eFIP 18328268
Phosphorylation Q8IZP0 (ABI1) Y421 O14512 (SOCS7) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 O00459 (PIK3R2) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 O15357 (INPPL1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 Q8BMC3 (Shc2) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 P46109 (CRKL) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 P35235 (Ptpn11) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 Q9ULV8 (CBLC) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 P00520 (Abl1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 P46108 (CRK) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 Q13191 (CBLB) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P52735 (VAV2) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 Q13322 (GRB10) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P06239 (LCK) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P07948 (LYN) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P07332 (FES) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P42684 (ABL2) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 Q92569 (PIK3R3) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 Q08881 (ITK) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P16591 (FER) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P27986 (PIK3R1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P08631 (HCK) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P62993 (GRB2) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P15498 (VAV1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P20936 (RASA1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P10686 (Plcg1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P12931 (SRC) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P06241 (FYN) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P19174 (PLCG1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P06241 (FYN) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P00523 (SRC) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P07947 (YES1) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P42685 (FRK) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y421 P09769 (FGR) unknown eFIP 20598684
Phosphorylation Q8IZP0 (ABI1) Y213 P00519 (ABL1) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y37 H37 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S183 G183 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T215 N215 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T229 K229 Biomuta DOID:3571 / liver cancer [ icgc ]
T238 K238 Biomuta DOID:3571 / liver cancer [ icgc ]
S240 C240 Biomuta DOID:1909 / melanoma [ tcga ]
S243 G243 Biomuta DOID:1324 / lung cancer [ cosmic ]
S246 R246 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S327 L327 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]