iPTMnet Report for Q8IZH2 (XRN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZH2 / XRN1_HUMAN
Protein Name 5'-3' exoribonuclease 1
Gene Name Name: XRN1
Synonyms:SEP1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZH2
DAG View
PRO Name 5'-3' exoribonuclease 1 (human)
Definition A 5'-3' exoribonuclease 1 that is encoded in the genome of human.
Short Label hXRN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZH2 (XRN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K79 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
T753 Phosphorylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
Y797 Phosphorylation PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
K805 Ubiquitination PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
Y829 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
C893 Methylation IEDB 31844290
K910 Ubiquitination PhosphoSitePlus
R939 Methylation PhosphoSitePlus
K950 Ubiquitination PhosphoSitePlus
K971 Ubiquitination PhosphoSitePlus
Y990 Phosphorylation PhosphoSitePlus
K1035 Ubiquitination PhosphoSitePlus
K1130 Ubiquitination PhosphoSitePlus
S1173 Phosphorylation phospho.ELM 17081983
S1176 Phosphorylation phospho.ELM 17081983
K1228 Ubiquitination PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
Y1248 Phosphorylation PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
K1272 Ubiquitination PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
K1281 Ubiquitination PhosphoSitePlus
Y1282 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
K1301 Ubiquitination PhosphoSitePlus
S1306 Phosphorylation PhosphoSitePlus
K1308 Ubiquitination PhosphoSitePlus
S1348 Phosphorylation PhosphoSitePlus
K1364 Acetylation PhosphoSitePlus
K1364 Ubiquitination PhosphoSitePlus
K1374 Ubiquitination PhosphoSitePlus
K1378 Ubiquitination PhosphoSitePlus
S1387 O-Glycosylation GlyGen 30059200, 30620550, 35132862, ...31492838, 35254053, 29237092
Y1394 Phosphorylation PhosphoSitePlus
S1398 Phosphorylation PhosphoSitePlus
K1401 Ubiquitination PhosphoSitePlus
K1412 Acetylation PhosphoSitePlus
Y1419 Phosphorylation PhosphoSitePlus
S1451 Phosphorylation PhosphoSitePlus
K1621 Ubiquitination PhosphoSitePlus
T1629 O-Glycosylation GlyGen 32938750, 30059200, 30620550, ...35132862, 31492838, 35254053, 29237092
T1629 Phosphorylation PhosphoSitePlus
T1633 Phosphorylation PhosphoSitePlus
S1634 O-Glycosylation GlyGen 30059200, 30620550, 35132862, ...31492838, 35254053, 29237092
S1638 Phosphorylation PhosphoSitePlus
S1645 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1653 Phosphorylation PhosphoSitePlus
S1692 Phosphorylation PhosphoSitePlus
S1702 O-Glycosylation GlyGen 30059200, 30620550, 35132862, ...31492838, 35254053, 29237092
Site PTM Type PTM Enzyme Score Source PMID
Y1394 Phosphorylation HPRD 19664994
S1398 Phosphorylation HPRD 19664994
S1645 Phosphorylation HPRD 20068231
S1656 Phosphorylation HPRD 20068231
S1686 Phosphorylation HPRD 20068231
S1687 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S1348 Phosphorylation PhosphoSitePlus
K1355 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K572 N572 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K758 E758 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K818 T818 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K950 I950 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y990 C990 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1256 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K1256 N1256 Biomuta DOID:363 / uterine cancer [ icgc ]
K1355 N1355 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1387 F1387 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1394 C1394 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1451 F1451 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1653 F1653 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1656 F1656 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1702 Y1702 Biomuta DOID:363 / uterine cancer [ icgc ]