iPTMnet Report for Q8IZF0 (NALCN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZF0 / NALCN_HUMAN
Protein Name Sodium leak channel NALCN
Gene Name Name: NALCN
Synonyms:VGCNL1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZF0
DAG View
PRO Name sodium leak channel NALCN (human)
Definition A sodium leak channel NALCN that is encoded in the genome of human.
Short Label hNALCN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZF0 (NALCN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T165 Phosphorylation PhosphoSitePlus
N210 N-Glycosylation GlyGen   UniProt 33203861
N216 N-Glycosylation GlyGen   UniProt 33203861
S489 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
T623 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
T917 Phosphorylation PhosphoSitePlus
Y923 Phosphorylation PhosphoSitePlus
N1064 N-Glycosylation GlyGen   UniProt 33203861, 32698188
S1066 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
K1069 Acetylation PhosphoSitePlus
S1113 Phosphorylation IEDB 32387766
Y1298 Phosphorylation PhosphoSitePlus
Y1362 Phosphorylation PhosphoSitePlus
S1682 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y497 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S489 L489 Biomuta DOID:4159 / skin cancer [ cosmic ]
T623 I623 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S742 L742 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T917 N917 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y923 C923 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
N1064 I1064 Biomuta DOID:4159 / skin cancer [ cosmic ]
N1064 K1064 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1066 I1066 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1068 A1068 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1069 N1069 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]