iPTMnet Report for Q8IZE3 (SCYL3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZE3 / PACE1_HUMAN
Protein Name Protein-associating with the carboxyl-terminal domain of ezrin
Gene Name Name: SCYL3
Synonyms:PACE1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZE3
DAG View
PRO Name protein-associating with the carboxyl-terminal domain of ezrin (human)
Definition A protein-associating with the carboxyl-terminal domain of ezrin that is encoded in the genome of human.
Short Label hSCYL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZE3 (SCYL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 12651155
T153 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
K430 Ubiquitination PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S391 F391 Biomuta DOID:4159 / skin cancer [ cosmic ]
S405 F405 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S427 R427 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K430 T430 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S513 L513 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]