iPTMnet Report for Q8IZD2 (KMT2E)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZD2 / KMT2E_HUMAN
Protein Name Inactive histone-lysine N-methyltransferase 2E
Gene Name Name: KMT2E
Synonyms:MLL5;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZD2
DAG View
PRO Name inactive histone-lysine N-methyltransferase 2E (human)
Definition A histone-lysine N-methyltransferase 2E that is encoded in the genome of human.
Short Label hKMT2E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZD2 (KMT2E) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
Y41 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
T100 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
S185 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
T189 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
T214 Phosphorylation PhosphoSitePlus
S252 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
K256 Ubiquitination PhosphoSitePlus
S258 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
K276 Ubiquitination PhosphoSitePlus
S435 O-Glycosylation GlyGen   UniProt 26678539, 25670814, 30379171, ...30620550
T440 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 26678539, 25670814, 30379171, ...30620550
K472 Ubiquitination PhosphoSitePlus
S475 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
T487 Phosphorylation PhosphoSitePlus
S531 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
S531 Phosphorylation PhosphoSitePlus
S536 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
S538 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
S623 Phosphorylation PhosphoSitePlus   UniProt 23186163
S653 Phosphorylation PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
T778 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
T786 Phosphorylation PhosphoSitePlus
R792 Methylation PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus   UniProt 23186163
S843 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
S854 Phosphorylation IEDB   PhosphoSitePlus 27920218
S861 Phosphorylation PhosphoSitePlus
T912 Phosphorylation neXtProt   PhosphoSitePlus 20439461
T912 Phosphorylation P06493 (CDK1) PhosphoSitePlus 20439461
Y965 Phosphorylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus
T1001 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
T1001 Phosphorylation PhosphoSitePlus
S1002 O-Glycosylation GlyGen 26678539, 25670814, 30379171, ...30620550
S1002 Phosphorylation PhosphoSitePlus
T1062 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
S1070 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1088 Phosphorylation PhosphoSitePlus
T1147 Phosphorylation PhosphoSitePlus
S1273 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1340 Phosphorylation PhosphoSitePlus
S1355 Phosphorylation PhosphoSitePlus
S1359 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1444 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1070 Phosphorylation HPRD 18452278
S1405 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T47 P47 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K276 N276 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S435 I435 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
S536 L536 Biomuta DOID:1324 / lung cancer [ cosmic ]
S655 C655 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R792 K792 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S795 L795 Biomuta DOID:4159 / skin cancer [ cosmic ]
T912 M912 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1065 F1065 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1088 A1088 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1088 I1088 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1340 F1340 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1405 L1405 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]