iPTMnet Report for Q8IZC4 (RTKN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZC4 / RTKN2_HUMAN
Protein Name Rhotekin-2
Gene Name Name: RTKN2
Synonyms:PLEKHK1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IZC4
DAG View
PRO Name rhotekin-2 (human)
Definition A rhotekin-2 that is encoded in the genome of human.
Short Label hRTKN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZC4 (RTKN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K48 Ubiquitination PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S92 O-Glycosylation GlyGen 30379171, 35254053
K101 Ubiquitination PhosphoSitePlus
S116 O-Glycosylation GlyGen 30379171, 35254053
S120 O-Glycosylation GlyGen 30379171, 35254053
T187 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S116 F116 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S594 F594 Biomuta DOID:4159 / skin cancer [ cosmic ]