iPTMnet Report for Q8IZ69 (TRMT2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZ69 / TRM2A_HUMAN
Protein Name tRNA (uracil-5-)-methyltransferase homolog A
Gene Name Name: TRMT2A
Organism Homo sapiens (Human)

PRO ID PR:Q8IZ69
DAG View
PRO Name tRNA (uracil-5-)-methyltransferase homolog A (human)
Definition A tRNA (uracil-5-)-methyltransferase homolog A that is encoded in the genome of human.
Short Label hTRMT2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZ69 (TRMT2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y60 Phosphorylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
C111 Methylation IEDB 31844290
K135 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus   UniProt 23186163
K559 Ubiquitination PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
S602 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Site PTM Type PTM Enzyme Score Source PMID
S602 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K135 T135 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K242 T242 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K314 E314 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K375 N375 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]