iPTMnet Report for Q8IZ40 (RCOR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IZ40 / RCOR2_HUMAN
Protein Name REST corepressor 2
Gene Name Name: RCOR2
Organism Homo sapiens (Human)

PRO ID PR:Q8IZ40
DAG View
PRO Name REST corepressor 2 (human)
Definition A REST corepressor 2 that is encoded in the genome of human.
Short Label hRCOR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IZ40 (RCOR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus   UniProt 21406692
S35 Phosphorylation PhosphoSitePlus   UniProt 21406692
S36 Phosphorylation PhosphoSitePlus   UniProt 21406692
K60 Sumoylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus   UniProt 23186163
S68 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K91 Sumoylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
R479 Methylation PhosphoSitePlus
R491 Methylation PhosphoSitePlus
R498 Methylation PhosphoSitePlus
R502 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 N36 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S36 T36 Biomuta DOID:3571 / liver cancer [ cosmic ]
S36 R36 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S68 N68 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S168 I168 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S168 R168 Biomuta DOID:1324 / lung cancer [ cosmic ]
S202 N202 Biomuta DOID:4159 / skin cancer [ cosmic ]
S202 I202 Biomuta DOID:363 / uterine cancer [ icgc ]
R498 P498 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R502 P502 Biomuta DOID:10534 / stomach cancer [ cosmic ]