Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYW5 / RN168_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF168
Gene Name Name: RNF168
Organism Homo sapiens (Human)

PRO ID PR:Q8IYW5
DAG View
PRO Name E3 ubiquitin-protein ligase RNF168 (human)
Definition An E3 ubiquitin-protein ligase RNF168 that is encoded in the genome of human.
Short Label hRNF168
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYW5 (RNF168) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Sumoylation PRO
S59 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus   UniProt 23186163
K140 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
K210 Sumoylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S411 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S414 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S415 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T421 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T426 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K468 Sumoylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus   UniProt 23186163
T479 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049053 (hRNF168/SumoLys+) su PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60341 (KDM1A) S131 Q8IYW5 (RNF168) unknown eFIP 25999347


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 L59 Biomuta DOID:1612 / breast cancer [ icgc ]
S70 Y70 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y104 C104 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K112 N112 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K158 N158 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K232 E232 Biomuta DOID:363 / uterine cancer [ tcga ]
K323 E323 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S411 P411 Biomuta DOID:3571 / liver cancer [ tcga ]
K485 E485 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K506 E506 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K524 N524 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K528 N528 Biomuta DOID:363 / uterine cancer [ tcga ]