Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYT8 / ULK2_HUMAN
Protein Name Serine/threonine-protein kinase ULK2
Gene Name Name: ULK2
Synonyms:KIAA0623;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYT8
DAG View
PRO Name serine/threonine-protein kinase ULK2 (human)
Definition A serine/threonine-protein kinase ULK2 that is encoded in the genome of human.
Short Label hULK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYT8 (ULK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K31 Sumoylation PhosphoSitePlus
K39 Sumoylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S468 Phosphorylation RLIMS-P 26052940
S528 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
T826 Phosphorylation PhosphoSitePlus
T844 Phosphorylation PhosphoSitePlus
K922 Acetylation PhosphoSitePlus
Y1018 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P 26052940


Q8IYT8 (ULK2) as PTM Enzyme



Substrate Site Score Source PMID
A2RUS2 (DENND3) S472 PhosphoSitePlus 25925668
A2RUS2 (DENND3) S490 PhosphoSitePlus 25925668


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8IYT8 (ULK2) S1027 Q92973 (TNPO1) unknown eFIP 26052940
Phosphorylation Q8IYT8 (ULK2) S1027 O75143 (ATG13) increased_association eFIP 26052940


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S468 Y468 Biomuta DOID:3571 / liver cancer [ icgc ]
T844 K844 Biomuta DOID:3571 / liver cancer [ icgc ]
S1027 L1027 Biomuta DOID:363 / uterine cancer [ tcga ]