iPTMnet Report for Q8IYT8 (ULK2)
Protein Information
| UniProt AC / UniProt ID | Q8IYT8 / ULK2_HUMAN |
| Protein Name | Serine/threonine-protein kinase ULK2 |
| Gene Name | Name: ULK2 Synonyms:KIAA0623; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8IYT8 |
| PRO Name | serine/threonine-protein kinase ULK2 (human) |
| Definition | A serine/threonine-protein kinase ULK2 that is encoded in the genome of human. |
| Short Label | hULK2 |
| Category | organism-gene |
DAG ViewQ8IYT8 (ULK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K31 | Sumoylation | score1 | PhosphoSitePlus | |||
| K39 | Sumoylation | score1 | PhosphoSitePlus | |||
| S104 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S148 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S150 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S323 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y331 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T425 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S430 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S468 | Phosphorylation | score0 | RLIMS-P | 26052940 | ||
| S528 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T531 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S574 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T576 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S600 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T613 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
| S729 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S771 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T826 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T844 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K922 | Acetylation | score1 | PhosphoSitePlus | |||
| Y1018 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1027 | Phosphorylation | P17612 (PRKACA) | score3 | PhosphoSitePlus RLIMS-P | 26052940 |
Q8IYT8 (ULK2) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| A2RUS2 (DENND3) | S472 | score3 | PhosphoSitePlus Signor | 25925668 | |
| A2RUS2 (DENND3) | S490 | score3 | PhosphoSitePlus Signor | 25925668 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q8IYT8 (ULK2) | S1027 | Q92973 (TNPO1) | unknown | eFIP | 26052940 | |
| Phosphorylation | Q8IYT8 (ULK2) | S1027 | O75143 (ATG13) | increased_association | eFIP | 26052940 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S323 | F323 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S1027 | L1027 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
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