iPTMnet Report for Q8IYT2 (CMTR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYT2 / CMTR2_HUMAN
Protein Name Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Gene Name Name: CMTR2
Synonyms:AFT,FTSJD1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYT2
DAG View
PRO Name cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (human)
Definition A cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 that is encoded in the genome of human.
Short Label hCMTR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYT2 (CMTR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
C144 Methylation IEDB 31844290
C283 Methylation IEDB 31844290
K332 Ubiquitination PhosphoSitePlus
T334 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K442 Methylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K97 R97 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K387 E387 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K422 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K422 Q422 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K422 T422 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K432 E432 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K448 E448 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K456 T456 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K536 * Biomuta DOID:1324 / lung cancer [ cosmic ]