iPTMnet Report for Q8IYR6 (TMEFF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYR6 / TEFF1_HUMAN
Protein Name Tomoregulin-1 precursor
Gene Name Name: TMEFF1
Synonyms:C9orf2;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYR6
DAG View
PRO Name tomoregulin-1 (human)
Definition A tomoregulin-1 that is encoded in the genome of human.
Short Label hTMEFF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYR6 (TMEFF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N63 N-Glycosylation GlyGen 24190977
T117 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K365 Acetylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K246 N246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T375 M375 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T375 S375 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]