iPTMnet Report for Q8IYR2 (SMYD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYR2 / SMYD4_HUMAN
Protein Name SET and MYND domain-containing protein 4
Gene Name Name: SMYD4
Synonyms:KIAA1936;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYR2
DAG View
PRO Name SET and MYND domain-containing protein 4 (human)
Definition A SET and MYND domain-containing protein 4 that is encoded in the genome of human.
Short Label hSMYD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYR2 (SMYD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
C572 Methylation IEDB 31844290
K577 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K63 N63 Biomuta DOID:4159 / skin cancer [ cosmic ]
K144 M144 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K377 E377 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K789 E789 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]