iPTMnet Report for Q8IYM9 (TRIM22)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYM9 / TRI22_HUMAN
Protein Name E3 ubiquitin-protein ligase TRIM22
Gene Name Name: TRIM22
Synonyms:RNF94,STAF50;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYM9
DAG View
PRO Name E3 ubiquitin-protein ligase TRIM22 (human)
Definition An E3 ubiquitin-protein ligase TRIM22 that is encoded in the genome of human.
Short Label hTRIM22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYM9 (TRIM22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K44 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
C140 Methylation IEDB 31844290
K173 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
S244 Phosphorylation RLIMS-P 24983760
T325 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
T460 Phosphorylation RLIMS-P 24983760


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S46 L46 Biomuta DOID:4159 / skin cancer [ cosmic ]
K185 R185 Biomuta DOID:363 / uterine cancer [ icgc ]
S244 L244 Biomuta DOID:4159 / skin cancer [ cosmic ]
K382 T382 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S383 R383 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S384 Y384 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K396 N396 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
T460 I460 Biomuta DOID:9256 / colorectal cancer [ cosmic ]