iPTMnet Report for Q8IYM2 (SLFN12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYM2 / SLN12_HUMAN
Protein Name Ribonuclease SLFN12
Gene Name Name: SLFN12
Organism Homo sapiens (Human)

PRO ID PR:Q8IYM2
DAG View
PRO Name ribonuclease SLFN12 (human)
Definition A ribonuclease SLFN12 that is encoded in the genome of human.
Short Label hSLFN12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYM2 (SLFN12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T333 Phosphorylation HPRD   PhosphoSitePlus 20058876
S368 Phosphorylation PhosphoSitePlus   UniProt 35104454
K398 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus
K490 Acetylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus   UniProt 35104454


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T333 I333 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S416 C416 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y510 C510 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y522 D522 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y529 N529 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]