iPTMnet Report for Q8IYL2 (TRMT44)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYL2 / TRM44_HUMAN
Protein Name Probable tRNA (uracil-O(2)-)-methyltransferase
Gene Name Name: TRMT44
Synonyms:C4orf23,METTL19;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYL2
DAG View
PRO Name probable tRNA (uracil-O(2)-)-methyltransferase (human)
Definition A probable tRNA (uracil-O(2)-)-methyltransferase that is encoded in the genome of human.
Short Label hTRMT44
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYL2 (TRMT44) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S65 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus   UniProt 23186163
K189 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus   UniProt 23186163
T628 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
T658 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
C729 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K389 Q389 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K389 T389 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T628 S628 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S630 R630 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T658 I658 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]