iPTMnet Report for Q8IYD1 (GSPT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYD1 / ERF3B_HUMAN
Protein Name Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
Gene Name Name: GSPT2
Synonyms:ERF3B;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYD1
DAG View
PRO Name eukaryotic peptide chain release factor GTP-binding subunit ERF3B (human)
Definition A eukaryotic peptide chain release factor GTP-binding subunit ERF3B that is encoded in the genome of human.
Short Label hGSPT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYD1 (GSPT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation PhosphoSitePlus
R74 Methylation PhosphoSitePlus
T81 O-Glycosylation GlyGen 30379171, 35132862
K102 Acetylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
S293 O-Glycosylation GlyGen 31373491
K316 Ubiquitination PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
K325 Acetylation PhosphoSitePlus
K325 Methylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K369 Acetylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K375 Acetylation PhosphoSitePlus
K376 Acetylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K598 Acetylation PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
T607 Phosphorylation PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
K619 Acetylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K622 Acetylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R74 W74 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
R74 G74 Biomuta DOID:1324 / lung cancer [ cosmic ]
S113 F113 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S196 L196 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K267 N267 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S293 T293 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S293 R293 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S380 C380 Biomuta DOID:263 / kidney cancer [ cosmic ]
T444 P444 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K598 E598 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]