iPTMnet Report for Q8IYB7 (DIS3L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IYB7 / DI3L2_HUMAN
Protein Name DIS3-like exonuclease 2
Gene Name Name: DIS3L2
Synonyms:FAM6A;
Organism Homo sapiens (Human)

PRO ID PR:Q8IYB7
DAG View
PRO Name DIS3-like exonuclease 2 (human)
Definition A DIS3-like exonuclease 2 that is encoded in the genome of human.
Short Label hDIS3L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IYB7 (DIS3L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
R17 Methylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K36 Acetylation PhosphoSitePlus
K38 Methylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus   UniProt 24275569
S175 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K252 Acetylation PhosphoSitePlus   UniProt 19608861
K283 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
T662 Phosphorylation PhosphoSitePlus
Y721 Phosphorylation PhosphoSitePlus
Y789 Phosphorylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus   UniProt 23186163
S885 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation HPRD 20068231
S875 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y137 H137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S139 L139 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K596 E596 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T662 A662 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y721 C721 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y789 C789 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]