Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IY92 / SLX4_HUMAN
Protein Name Structure-specific endonuclease subunit SLX4
Gene Name Name: SLX4
Synonyms:BTBD12,KIAA1784,KIAA1987;
Organism Homo sapiens (Human)

PRO ID PR:Q8IY92
DAG View
PRO Name structure-specific endonuclease subunit SLX4 (human)
Definition A structure-specific endonuclease subunit SLX4 that is encoded in the genome of human.
Short Label hSLX4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IY92 (SLX4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus   UniProt 23186163
S173 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus   UniProt 18669648
K291 Sumoylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K359 Sumoylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
K404 Methylation PhosphoSitePlus
K405 Methylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
T478 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
T832 Phosphorylation PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus
S956 Phosphorylation PhosphoSitePlus
S1028 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1044 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
R1046 Methylation PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
R1062 Methylation PhosphoSitePlus
T1065 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
S1070 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1072 Phosphorylation PhosphoSitePlus
S1075 Phosphorylation PhosphoSitePlus
S1087 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus
K1093 Ubiquitination PhosphoSitePlus
K1120 Ubiquitination PhosphoSitePlus
S1123 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation PhosphoSitePlus
S1138 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S1157 Phosphorylation PhosphoSitePlus
K1169 Ubiquitination PhosphoSitePlus
S1170 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
K1179 Ubiquitination PhosphoSitePlus
K1180 Sumoylation PhosphoSitePlus
S1185 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1260 Phosphorylation PhosphoSitePlus
S1264 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
T1273 Phosphorylation PhosphoSitePlus
T1288 Phosphorylation PhosphoSitePlus
T1291 Phosphorylation PhosphoSitePlus
S1309 Phosphorylation PhosphoSitePlus
T1315 Phosphorylation PhosphoSitePlus
T1320 Phosphorylation PhosphoSitePlus
S1322 Phosphorylation PhosphoSitePlus
S1323 Phosphorylation PhosphoSitePlus
T1326 Phosphorylation PhosphoSitePlus
S1329 Phosphorylation PhosphoSitePlus
T1332 Phosphorylation PhosphoSitePlus
S1333 Phosphorylation PhosphoSitePlus
S1342 Phosphorylation PhosphoSitePlus
S1355 Phosphorylation PhosphoSitePlus
S1398 Phosphorylation PhosphoSitePlus
T1446 Phosphorylation PhosphoSitePlus
S1452 Phosphorylation PhosphoSitePlus
S1453 Phosphorylation PhosphoSitePlus
S1455 Phosphorylation PhosphoSitePlus
S1464 Phosphorylation PhosphoSitePlus
S1469 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
T1476 Phosphorylation PhosphoSitePlus
K1491 Ubiquitination PhosphoSitePlus
K1575 Sumoylation PhosphoSitePlus
S1631 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
K1657 Ubiquitination PhosphoSitePlus
T1676 Phosphorylation PhosphoSitePlus
S1681 Phosphorylation PhosphoSitePlus
T1683 Phosphorylation PhosphoSitePlus
S1716 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
Site PTM Type PTM Enzyme Score Source PMID
S287 Phosphorylation HPRD 18669648
S884 Phosphorylation HPRD 18691976
S1044 Phosphorylation HPRD 18691976, 19664994, 19664995, ...20068231
S1070 Phosphorylation HPRD 20068231
S1075 Phosphorylation HPRD 20068231
S1185 Phosphorylation HPRD 20068231
S1452 Phosphorylation HPRD 19664995
S1453 Phosphorylation HPRD 19664995
S1469 Phosphorylation HPRD 18669648, 19664994, 20068231
T1475 Phosphorylation HPRD 20068231
S1674 Phosphorylation HPRD 20068231
S1679 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96NY9 (MUS81) S87 Q8IY92 (SLX4) unknown eFIP 29850896


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S173 C173 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S348 R348 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K412 N412 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T500 M500 Biomuta DOID:1909 / melanoma [ cosmic ]
S1044 I1044 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R1062 C1062 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:9256 / colorectal cancer [ icgc ]
K1120 Q1120 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1134 L1134 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S1157 L1157 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K1179 T1179 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T1260 P1260 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S1271 F1271 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T1315 A1315 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
T1315 I1315 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
S1342 G1342 Biomuta DOID:363 / uterine cancer [ tcga ]
K1575 R1575 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1681 L1681 Biomuta DOID:1909 / melanoma [ icgc, tcga ]