Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IY81 / SPB1_HUMAN
Protein Name pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Gene Name Name: FTSJ3
ORFNames:SB92;
Organism Homo sapiens (Human)

PRO ID PR:Q8IY81
DAG View
PRO Name pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (human)
Definition An rRNA methyltransferase 3 that is encoded in the genome of human.
Short Label hFTSJ3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IY81 (FTSJ3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
K233 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S333 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278, ...18669648, 24275569, 19690332, 20068231
S335 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...18691976, 18452278, 19651622, 18669648, 19415658, 24275569, 19690332, 20068231
S336 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...18691976, 19691289, 18452278, 19651622, 18669648, 19415658, 19690332, 20068231
S347 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T348 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T352 Phosphorylation HPRD   phospho.ELM 18669648
S356 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T371 Phosphorylation HPRD   PhosphoSitePlus 18452278
K376 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
S441 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S448 Phosphorylation PhosphoSitePlus
S458 Phosphorylation HPRD   PhosphoSitePlus 17081983, 18452278
T467 Phosphorylation HPRD   PhosphoSitePlus 17081983
S468 Phosphorylation HPRD 17081983, 18452278
S471 Phosphorylation HPRD   PhosphoSitePlus 18452278
S549 Phosphorylation PhosphoSitePlus   UniProt 19690332
K567 Ubiquitination PhosphoSitePlus
T573 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17322306, ...18669648, 20068231
S576 Phosphorylation PhosphoSitePlus
K579 Sumoylation PhosphoSitePlus
T580 Phosphorylation HPRD   PhosphoSitePlus 19007248, 19691289
S584 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 20058876, ...16565220, 18767875, 19664994, 19664995, 19007248, 19651622, 18669648, 23186163, 18452278, 19690332, 20068231, 19691289
Y587 Phosphorylation HPRD   PhosphoSitePlus 19413330
T595 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S599 Phosphorylation HPRD   PhosphoSitePlus 18452278, 19691289, 20068231, ...19007248
T601 Phosphorylation HPRD   PhosphoSitePlus 19413330
T605 Phosphorylation PhosphoSitePlus
S616 Phosphorylation HPRD   phospho.ELM 17081983
S618 Phosphorylation HPRD   phospho.ELM 17081983
S620 Phosphorylation HPRD   phospho.ELM 17081983
S621 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
T622 Phosphorylation HPRD   phospho.ELM 17081983
S623 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18452278
S624 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S639 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S644 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
K659 Ubiquitination PhosphoSitePlus
S676 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...17924679
S677 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 17924679
K678 Acetylation PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S688 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18767875, ...19664994, 19007248, 16565220, 19651622, 18669648, 20068231, 19691289
K710 Ubiquitination PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
K788 Methylation PhosphoSitePlus
K793 Acetylation PhosphoSitePlus
Y800 Phosphorylation PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K218 N218 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T226 N226 Biomuta DOID:1612 / breast cancer [ tcga ]
Y241 C241 Biomuta DOID:184 / bone cancer [ icgc ] DOID:3371 / chondrosarcoma [ cosmic ]
S347 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
S468 C468 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T605 N605 Biomuta DOID:263 / kidney cancer [ cosmic ]
S620 R620 Biomuta DOID:3571 / liver cancer [ icgc ]
S624 I624 Biomuta DOID:1612 / breast cancer [ tcga ]
S639 I639 Biomuta DOID:363 / uterine cancer [ tcga ]