iPTMnet Report for Q8IY21 (DDX60)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IY21 / DDX60_HUMAN
Protein Name Probable ATP-dependent RNA helicase DDX60
Gene Name Name: DDX60
Organism Homo sapiens (Human)

PRO ID PR:Q8IY21
DAG View
PRO Name probable ATP-dependent RNA helicase DDX60 (human)
Definition A probable ATP-dependent RNA helicase DDX60 that is encoded in the genome of human.
Short Label hDDX60
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IY21 (DDX60) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K234 Ubiquitination PhosphoSitePlus
C309 Methylation IEDB 31844290
K434 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
Y535 Phosphorylation PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
K563 Acetylation PhosphoSitePlus
K569 Acetylation PhosphoSitePlus
K571 Acetylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
C634 Methylation IEDB 31844290
K700 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
Y729 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
Y793 Phosphorylation PhosphoSitePlus
Y796 Phosphorylation PhosphoSitePlus
K804 Ubiquitination PhosphoSitePlus
K834 Ubiquitination PhosphoSitePlus
T949 Phosphorylation PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
K969 Ubiquitination PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
T1024 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
K1061 Ubiquitination PhosphoSitePlus
K1085 Ubiquitination PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
S1106 Phosphorylation PhosphoSitePlus
T1112 Phosphorylation PhosphoSitePlus
K1172 Ubiquitination PhosphoSitePlus
K1212 Ubiquitination PhosphoSitePlus
K1216 Ubiquitination PhosphoSitePlus
K1230 Ubiquitination PhosphoSitePlus
K1239 Ubiquitination PhosphoSitePlus
K1245 Acetylation PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
S1266 Phosphorylation HPRD 19651622
S1365 Phosphorylation PhosphoSitePlus
T1367 Phosphorylation PhosphoSitePlus
S1416 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y1425 Phosphorylation IEDB 35494241
K1559 Ubiquitination PhosphoSitePlus
K1628 Ubiquitination PhosphoSitePlus
S1637 Phosphorylation HPRD   PhosphoSitePlus 19651622
Y1646 Phosphorylation HPRD   PhosphoSitePlus 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C309 F309 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C309 Y309 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K475 N475 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K492 N492 Biomuta DOID:4159 / skin cancer [ cosmic ]
S561 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K571 E571 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y796 H796 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K834 T834 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K834 R834 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K1061 E1061 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1112 I1112 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1239 N1239 Biomuta DOID:1319 / brain cancer [ icgc ]
K1245 T1245 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K1245 Q1245 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1254 N1254 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1628 N1628 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1637 L1637 Biomuta DOID:9256 / colorectal cancer [ cosmic ]