iPTMnet Report for Q8IY18 (SMC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IY18 / SMC5_HUMAN
Protein Name Structural maintenance of chromosomes protein 5
Gene Name Name: SMC5
Synonyms:KIAA0594,SMC5L1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IY18
DAG View
PRO Name structural maintenance of chromosomes protein 5 (human)
Definition A structural maintenance of chromosomes protein 5 that is encoded in the genome of human.
Short Label hSMC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IY18 (SMC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S16 Phosphorylation PhosphoSitePlus
S25 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
S26 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S35 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 22067460, 18669648, ...24275569, 19690332
S44 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K100 Ubiquitination PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T199 Phosphorylation HPRD   PhosphoSitePlus 20068231
K210 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
C393 Methylation IEDB 31844290
K414 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K548 Acetylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
Y619 Phosphorylation PhosphoSitePlus
Y626 Phosphorylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
K740 Ubiquitination PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus
T754 Phosphorylation PhosphoSitePlus
S779 Phosphorylation HPRD   PhosphoSitePlus 18491316
S792 Phosphorylation PhosphoSitePlus
S793 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K895 Ubiquitination PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
K925 Ubiquitination PhosphoSitePlus
K933 Ubiquitination PhosphoSitePlus
T987 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T1046 Phosphorylation PhosphoSitePlus
S1047 Phosphorylation PhosphoSitePlus
Y1062 Phosphorylation PhosphoSitePlus
T1096 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S25 L25 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K31 N31 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K210 T210 Biomuta DOID:363 / uterine cancer [ cosmic ]
K232 N232 Biomuta DOID:4159 / skin cancer [ cosmic ]
K269 R269 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K498 T498 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S506 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K558 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K618 N618 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T751 I751 Biomuta DOID:4159 / skin cancer [ cosmic ]
S779 F779 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S792 P792 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S792 Y792 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K908 N908 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T987 A987 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]