iPTMnet Report for Q8IXW5 (RPAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IXW5 / RPAP2_HUMAN
Protein Name Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
Gene Name Name: RPAP2
Synonyms:C1orf82;
Organism Homo sapiens (Human)

PRO ID PR:Q8IXW5
DAG View
PRO Name putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (human)
Definition A putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 that is encoded in the genome of human.
Short Label hRPAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IXW5 (RPAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S9 Phosphorylation PhosphoSitePlus   UniProt 23186163
T29 O-Glycosylation GlyGen 31492838, 35254053
T31 Phosphorylation PhosphoSitePlus
S38 O-Glycosylation GlyGen 31492838, 35254053
T123 O-Glycosylation GlyGen 31492838, 35254053
K125 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
C288 Methylation IEDB 31844290
T297 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S433 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K444 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus   UniProt 21406692
K509 Acetylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S414 Phosphorylation HPRD 19651622
S433 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K171 N171 Biomuta DOID:363 / uterine cancer [ icgc ]
S315 F315 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y319 H319 Biomuta DOID:5158 / pleural cancer [ cosmic ]