iPTMnet Report for Q8IXS8 (HYCC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IXS8 / HYCC2_HUMAN
Protein Name Hyccin 2
Gene Name Name: HYCC2
Synonyms:FAM126B;
Organism Homo sapiens (Human)

PRO ID PR:Q8IXS8
DAG View
PRO Name hyccin 2 (human)
Definition A hyccin 2 that is encoded in the genome of human.
Short Label hFAM126B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IXS8 (HYCC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y42 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
T306 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163
T308 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
S313 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S367 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus   UniProt 23186163
S442 Phosphorylation PhosphoSitePlus   UniProt 23186163
S444 Phosphorylation PhosphoSitePlus   UniProt 23186163
S456 Phosphorylation PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus   UniProt 23186163
R496 Methylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y42 C42 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S367 T367 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S402 L402 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S456 * Biomuta DOID:363 / uterine cancer [ cosmic ]
Y487 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T489 I489 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R496 W496 Biomuta DOID:1319 / brain cancer [ icgc ]