Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IXJ9 / ASXL1_HUMAN
Protein Name Polycomb group protein ASXL1
Gene Name Name: ASXL1
Synonyms:KIAA0978;
Organism Homo sapiens (Human)

PRO ID PR:Q8IXJ9
DAG View
PRO Name Polycomb group protein ASXL1 (human)
Definition A Polycomb group protein ASXL1 that is encoded in the genome of human.
Short Label hASXL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IXJ9 (ASXL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S199 O-Glycosylation GlyGen 29556021, 21740066, 30397120
S201 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
T469 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus   UniProt 23186163
S503 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S526 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
R606 Methylation PhosphoSitePlus
T844 Phosphorylation PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
K1025 Acetylation PhosphoSitePlus
T1056 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
K1174 Ubiquitination PhosphoSitePlus
T1194 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
S1250 Phosphorylation PhosphoSitePlus
S1253 Phosphorylation PhosphoSitePlus
S1262 Phosphorylation PhosphoSitePlus
S1276 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
K1371 Ubiquitination PhosphoSitePlus
K1379 Ubiquitination PhosphoSitePlus
K1419 Ubiquitination PhosphoSitePlus
K1437 Ubiquitination PhosphoSitePlus
K1443 Ubiquitination PhosphoSitePlus
K1446 Ubiquitination PhosphoSitePlus
T1494 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S503 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S51 F51 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K362 N362 Biomuta DOID:3571 / liver cancer [ icgc ]
Y449 C449 Biomuta DOID:1324 / lung cancer [ cosmic ]
S501 P501 Biomuta DOID:3571 / liver cancer [ tcga ]
S526 F526 Biomuta DOID:1909 / melanoma [ tcga ]
T557 A557 Biomuta DOID:1324 / lung cancer [ tcga ]
S577 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R606 L606 Biomuta DOID:1324 / lung cancer [ tcga ]
T844 P844 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S1209 N1209 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1341 N1341 Biomuta DOID:1909 / melanoma [ cosmic ]
S1344 F1344 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K1443 R1443 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]