Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IXJ6 / SIR2_HUMAN
Protein Name NAD-dependent protein deacetylase sirtuin-2
Gene Name Name: SIRT2
Synonyms:SIR2L,SIR2L2;
Organism Homo sapiens (Human)

PRO ID PR:Q8IXJ6
DAG View
PRO Name NAD-dependent protein deacetylase sirtuin-2 (human)
Definition An NAD-dependent protein deacetylase sirtuin-2 that is encoded in the genome of human.
Short Label hSIRT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IXJ6 (SIRT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S23 Phosphorylation PhosphoSitePlus   UniProt 24275569
S25 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 24275569
S27 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 24275569
S50 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
T101 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 24446434
Y104 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P+   Signor 24996174
K126 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
R316 Methylation PhosphoSitePlus
K338 Acetylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T365 Phosphorylation phospho.ELM 18669648
S366 Phosphorylation PhosphoSitePlus
S368 Phosphorylation P06493 (CDK1) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17488717, 23186163, 18332217, ...17516032, 18669648
S372 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17516032
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 19413330, 19651622, 20166139
S25 Phosphorylation HPRD 19651622, 20166139
S27 Phosphorylation HPRD 19413330, 19651622
S46 Phosphorylation HPRD 17081983
T365 Phosphorylation HPRD 18669648
S366 Phosphorylation HPRD 20068231
S368 Phosphorylation HPRD 18510355, 19413330, 18669648, ...17081983
Site PTM Type PTM Enzyme Score Source PMID
T328 Phosphorylation HPRD 18669648
S329 Phosphorylation HPRD 20068231
S331 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 19413330, 26303530, 17081983, ...18669648, 18510355


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31350 (RRM2) S150 Q8IXJ6 (SIRT2) increased_association eFIP 31324785


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K212 N212 Biomuta DOID:1324 / lung cancer [ tcga ]
S356 L356 Biomuta DOID:363 / uterine cancer [ icgc ]
S366 L366 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S366 T366 Biomuta DOID:1324 / lung cancer [ tcga ]